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Chemotherapy

  • Chapter
Colorectal Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 83))

Abstract

Carcinomas of the colon and rectum have certain characteristics which indicate a potential role for chemotherapy in their management. Principal among these is the fact that the disease appears widespread in a majority of cases. This can be concluded from the failure of local forms of management — primarily surgery alone — to cure more than 30% of cases overall, despite an apparently curative resection. Once bowel is resected, the Dukes’ staging system can be used as a crude indicator of the risk of subsequent clinical relapse, but for the patient with demonstrable metastases at the time of operation, the median survival is less than 1 year. This compares with a 5-year survival rate of 30% for patients with apparently localized Dukes’ C tumours.

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Authors and Affiliations

  1. CRC Medical Oncology Unit, Southampton General Hospital, Southampton, S09 4XY, UK

    J. M. A. Whitehouse

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  1. J. M. A. Whitehouse
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Editors and Affiliations

  1. Department of Radiation Oncology, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK

    William Duncan

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© 1982 Springer-Verlag Berlin · Heidelberg

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Whitehouse, J.M.A. (1982). Chemotherapy. In: Duncan, W. (eds) Colorectal Cancer. Recent Results in Cancer Research, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81802-8_12

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  • DOI: https://doi.org/10.1007/978-3-642-81802-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81804-2

  • Online ISBN: 978-3-642-81802-8

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