Abstract
Identification of an insulinotropic action for GIP in man and development of a radioimmunoassay suitable for serum determinations led to a series of investigations into a possible role for the hormone in diabetes mellitus. Perley and Kipnis (1967) and Cerasi et al. (1973) had indicated that the enteroinsular axis was active or even hyperactive in maturity-onset diabetes. This later suggested to several groups a possible involvement of GIP, which has been considered to be a major component of the axis, in diabetic situations.
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© 1982 Springer-Verlag Berlin, Heidelberg
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Brown, J.C. (1982). Pathophysiology. In: Gastric Inhibitory Polypeptide. Monographs on Endocrinology, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81771-7_6
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DOI: https://doi.org/10.1007/978-3-642-81771-7_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81773-1
Online ISBN: 978-3-642-81771-7
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