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Hematoporphyrin Derivative as a Tumor Marker in the Detection and Localization of Pulmonary Malignancy

  • Chapter
Early Detection and Localization of Lung Tumors in High Risk Groups

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 82))

Abstract

Although a number of compounds, including eosin [14, 35], fluorescein [7, 26], tetracyclines [32, 37], and acridine orange [36], are known to induce fluorescence in tumors, the porphyrins have received greatest attention. Of this latter group, hematoporphyrin and its derivatives seem to be the most effective in inducing fluorescence [1, 2, 11, 38] and therefore have been considered the most likely to prove useful in the detection and localization of lung tumors. Equally of interest are the photodynamic properties of porphyrins which, when concentrated and localized within tumor tissue, render the malignancy susceptible to phototherapy [8].

The authors would like to thank Mrs. Darlene Odynski, Mrs. Ruby Miller, Drs. Jean leRiche and Roger Amy, and Mrs. Margaret Napier for their participation in the study reported in the review

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Authors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    E. G. King, D. Doiron, G. Man, A. E. Profio & G. Huth

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  1. E. G. King
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  2. D. Doiron
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  3. G. Man
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  4. A. E. Profio
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  5. G. Huth
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Editors and Affiliations

  1. Institut du Cancer de Montréal, Centre Hospitalier Notre-Dame, 1560 Est, H2L 4M1, Sherbrooke, Montréal, Canada

    Pierre R. Band M.D.

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© 1982 Springer-Verlag Berlin · Heidelberg

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King, E.G., Doiron, D., Man, G., Profio, A.E., Huth, G. (1982). Hematoporphyrin Derivative as a Tumor Marker in the Detection and Localization of Pulmonary Malignancy. In: Band, P.R. (eds) Early Detection and Localization of Lung Tumors in High Risk Groups. Recent Results in Cancer Research, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81768-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-81768-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81770-0

  • Online ISBN: 978-3-642-81768-7

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