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Nontumoral Hyperprolactinemia

  • Chapter
Prolactin

Part of the book series: Monographs on Endocrinology ((ENDOCRINOLOGY,volume 23))

Abstract

In the first chapter the dopaminergic mechanisms controlling PRL release have been amply analyzed. Most PRL-stimulating agents act by blocking DA synthesis or DA receptors (e. g., neuroleptics), depleting central catecholamine stores (e. g., reserpine) (Turkington 1972d; Lee et al. 1976) or interfering with some step of its synthesis (e.g., α-methyl-dopa or 3-I-L tyrosine) (Steiner et al. 1976; Smythe et al. 1975). Figure 4.1 presents the stimulatory action on PRL secretion of TRH and several DA-blocking agents in current clinical use. The administration of some of these drugs has been proposed as a clinical test of pituitary PRL reserve.

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Authors and Affiliations

  1. Pharmaceutical Division, Preclinical Research, Sandoz Ltd., Basle, Switzerland

    Edward W. Flückiger

  2. Pharmaceutical Division, Experimental Therapeutics, Sandoz Ltd., Basle, Switzerland

    Emilio del Pozo

  3. Department of Medicine Innenstadt, University of Munich, Munich, Federal Republic of Germany

    Klaus von Werder

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  1. Edward W. Flückiger
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  2. Emilio del Pozo
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  3. Klaus von Werder
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Flückiger, E.W., del Pozo, E., von Werder, K. (1982). Nontumoral Hyperprolactinemia. In: Prolactin. Monographs on Endocrinology, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81721-2_4

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