Macrophages in the Regulation of Immunity

  • C. Huber
  • G. Stingl
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 27)

Abstract

According to the classical view macrophages are prone to ingest and to destruct antigens and intracellular pathogens. More recently it became apparent that macrophages, besides their phagocytic capacities, are involved in the activation and regulation of lymphocyte functions. This article aims to summarize some recent findings on the role of macrophages during the afferent phase of immune responses.

Keywords

Polypeptide Nylon Allo Concanavaline Trinitrophenyl 

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References

  1. 1.
    Ahmann GB, Sachs DH, Hodes RS (1978) Requirement for an la bearing accessory cell in Con A induced T cell proliferation. J Immunol 121: 1981PubMedGoogle Scholar
  2. 2.
    Barnstable CS, Jones EA (1978) Isolation structure and genetics of HLA-A, -B, -C and –DR w (la) antigens. Br Med Bull 34: 241PubMedGoogle Scholar
  3. 3.
    Benacerraf B, Germain RN (1978) The immune response genes of the major histocompatibility complex. Immunol Rev 38: 70PubMedCrossRefGoogle Scholar
  4. 4.
    Rosenstreich DL, Farrar JJ, Dougherty S (1976) Absolute macrophage dependency of T lymphocyte activation by mitogens. J Immunol 116: 131PubMedGoogle Scholar
  5. 5.
    Shearer GM, Rehn TG, Garbarino CA (1975) Cell mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity of modified cell surface components controlled by the H2K and H2D serological regions of the murine major histocompatibility complex. J Exp Med 141: 1427CrossRefGoogle Scholar
  6. 6.
    Snell GD (1978) T cells, T cell recognition structures and the major histocompatibility complex. Immunol Rev 38: 3PubMedCrossRefGoogle Scholar
  7. 7.
    Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137: 1142PubMedCrossRefGoogle Scholar
  8. 8.
    Steinman RM, Witmer MD, Nussenzweig MC, Chen LL, Schlesinger S, Cohn ZA (1980) dendritic cells of the mouse: identification and characterization. J Invest Dermatol 75: 14PubMedCrossRefGoogle Scholar
  9. 9.
    Stingl G (1980) New aspects of Langerhans cell function. Int J Dermatol 19: 189PubMedCrossRefGoogle Scholar
  10. 10.
    Thomas DW, Yamashita U, Shevach EM (1977) The role of la antigens in T cell activation. Immunol Rev 35: 97CrossRefGoogle Scholar
  11. 11.
    Van Furth R, Cohn ZA, Hirsch JG, Humphrey JH, Spector WG, Langevoort HL (1972) The mononuclear phagocyte system: a new classification of macrophages, monocytes and their precursor cells. Bull WHO 46: 845PubMedGoogle Scholar
  12. 12.
    Wolff K (1972) The Langerhans cell. Curr Probl Dermatol 4: 79PubMedGoogle Scholar
  13. 13.
    Yamashita U, Shevach EM (1977) The expression of la antigens on immunocompetent cells in the guinea pig. II. Ia antigens on macrophages. J Immunol 119: 1584PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 1981

Authors and Affiliations

  • C. Huber
  • G. Stingl

There are no affiliations available

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