Effect of Individual Cytotoxic Agents Upon the Granulopoietic System
The nitrogen mustards have been the first agents with cytotoxic properties used for the treatment of malignancies. The most completely studied agent of this group of compounds is methyl-bis(β-chloroethyl)-amine (mechlorethamine) (HN2). HN2 has received the interest of experimental and clinical workers, and both have contributed to a better understanding of the effects of the agent on the granulopoietic system of experimental animals and human beings. In this review, attention will therefore be focussed on studies concerned with the hematopoietic toxicity of HN2. The effects of other nitrogen mustards, such as ethyl-bis(β-chloroethyl)-amine (HN1) or tris(β-chloroethyl)-amine (HN3), will be mentioned only briefly.
KeywordsDepression Testosterone Methotrexate Neutropenia Osteosarcoma
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