Summary
Burkitt’s-type leukemias have specific cytologic, immunologic, and cytogenetic characteristics. Initial symptomatology frequently includes abdominal tumors and initial CNS involvement. Despite intensive treatment including high-dose cyclophosphamide, prognosis remains poor in most patients because of failures to achieve complete remission (CR) or because of early relapses, especially CNS relapses. Class III acute lymphoblastic leukemia in children is defined by the presence of two or more unfavorable parameters and recent progress has been achieved by intensive therapy. Cox’s multifactorial analysis allows improved discrimination. A phase I protocol for increased-risk leukemias, including testis preventive irradiation and monthly reinductions without continuous maintenance for the first 6 months of CR, seems promising.
This research was carried out with the aid of Contrat INSERM, Commission 8; Subvention du Comité Franco-Américain de Recherche sur le Cancer (INSERM); USPHS Research Grant, CA 13239-05 from the National Cancer Institute; Caisse Régionale d Assurances Maladies de Paris; and Formation de Recherche Associé n°42 INSERM
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References
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukemias (FAB cooperation group). Br J Haematol 33:451–458
Berger R, Bernheim A, Brouet JC, Daniel MT, Flandrin G (1979) (8; 14) Translocation in a Burkitt’s type of lymphoblastic leukemia (L3). Br J Haematol 43:87–90
Brouet JC, Preud’homme JL, Seligmann M (1975) The use of B and T membrane markers in the classification of human leukemias with special reference to acute lymphoblastic leukemia. Blood Cells 1:81–90
Harousseau JL, Tobelem G, Schaison G, Chastang C, Auclerc MF, Weil M, Jacquillat CI, Bernard J (1978) High-risk acute lymphocytic leukemia. A study of 141 cases with high blast counts. Abstracts 17th Int Congr Hematol (Paris) 1:252
Jacquillat C, Le Gall E, Schaison G, Auclerc MF, Chastang C, Flandrin G (1978) Les leucémies aiguës avec localisation thymique. Actual Hematol 44:52
Jacquillat C, Weil M, Schaison G, Chastang C, Bernard J (1980) Results of protocol 08 LA 74 in childhood acute lymphoblastic leukemias. Proc Am Assoc Cancer Res 490:122
Ravidranath Y, Kaplan J, Zuelzer NN (1975) Significance of mediastinal mass in acute lymphoblastic leukemia. Pediatrics 55:889–893
Schaison G, Harvusseau JL, Jacquillat C, Weil M, Bernard J (1979) Phase I treatment protocol for children with increased-risk acute lymphocytic leukemia. Proc Am Assoc Cancer Res 419:104
Sen L, Borella L (1975) Clinical importance of lymphoblastes with markers in childhood acute leukemia. N Engl J Med 292: 828–832
Simone JV, Verzosa MS, Rudy J A (1975) Initial features and prognosis in 363 children with acute lymphoblastic leukemia. Cancer 36:2099–2108
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© 1982 Springer-Verlag Berlin · Heidelberg
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Weil, M., Jacquillat, C., Auclerc, M.F., Schaison, G., Chastang, C., Bernard, J. (1982). Poor-Prognosis Acute Lymphoblastic Leukemias. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_7
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DOI: https://doi.org/10.1007/978-3-642-81685-7_7
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