An Intensive Chemo- or Chemoimmunotherapy Regimen for Patients with Intermediate and Poor-Prognosis Acute Lymphatic Leukemia and Leukemic Lymphoblastic Lymphosarcoma: Preliminary Results with 14-Month Median Follow-Up

  • J. L. Misset
  • F. De Vassal
  • M. Delgado
  • P. Ribaud
  • M. Musset
  • T. Dorval
  • D. Machover
  • C. Jasmin
  • M. Hayat
  • L. Schwarzenberg
  • G. Mathe
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 80)

Abstract

We previously reported the prognostic factors that can be identified at the onset of acute lymphoid leukemia (ALL) [8]. The factors defining the prognosis are, according to our experience: the WHO Reference Center cytologic types (the “prolympho- blastic” type being always poor, the “microlymphoblastic” type good, and the “macrolymphoblastic” and the “prolymphocyte” intermediate [8]); the T-type is always poor, the null, as they were only characterized in our preceding protocols, intermediate [1]; and, in the cases of those above “intermediate” prognosis types, the volume (V) of the neoplasia plays a prognostic role, i.e., V+ (³ 104leukemic cells/mm3) and/or significant clinical masses suggest a poor prognosis [8].

Keywords

Toxicity Leukemia Oncol Stratification Methotrexate 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1982

Authors and Affiliations

  • J. L. Misset
    • 1
  • F. De Vassal
    • 1
  • M. Delgado
    • 1
  • P. Ribaud
    • 1
  • M. Musset
    • 1
  • T. Dorval
    • 1
  • D. Machover
    • 1
  • C. Jasmin
    • 1
  • M. Hayat
    • 1
  • L. Schwarzenberg
    • 1
  • G. Mathe
    • 1
  1. 1.Institut de Cancérologie et d’Immunogénétique, (INSERM U-40)Hôpital Paul-BrousseVillejuifFrance

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