Summary
Adjuvant chemotherapy trials in gastric and colorectal carcinomas are reviewed and no clear benefit from such treatment could be observed. To improve existing chemotherapy regimens, several pilot studies were performed in 95 gastric cancer and 85 colorectal carcinomas patients. Response rate for gastric carcinomas using the mitomycin C plus adriamycin plus 5-fluorouracil (5-FU) (FAM) regimen was 40% and was not improved by the addition of nitrosoureas. In colorectal carcinomas none of the combinations used gave better results than 5-FU alone. Fourteen patients with esophageal carcinoma were treated with combination CDDP and the response rate was as high as 50%.
This work was supported in part by the NCI French-American Cancer Research Agreement
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© 1982 Springer-Verlag Berlin · Heidelberg
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Gisselbrecht, C., Belpomme, D., Mignot, L., Marty, M., Mathé, G., Boiron, M. (1982). Chemotherapy of Carcinomas of the Digestive Tract. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_47
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DOI: https://doi.org/10.1007/978-3-642-81685-7_47
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