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Multimodal Therapy with CMF in Resectable Breast Cancer with Positive Axillary Nodes: The Milan Institute Experience

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 80))

Abstract

During the past few years, we have systematically published the short-term and the intermediate analysis of prospective randomized studies [4, 6, 15] with adjuvant combination chemotherapy in operable breast cancer having histologically positive axillary lymph nodes (N+). More recently, the 5-year results of the first trial were reported [11] as well as a retrospective analysis on the dose-response effect of adjuvant chemotherapy [2].

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References

  1. Bonadonna G, Rossi A, Valagussa P, Banfi A, Veronesi U (1977) The CMF program for operable breast cancer with positive axillary nodes. Updated analysis on the disease-free interval, site of relapse and drug tolerance. Cancer 39:2904–2915

    Article  PubMed  CAS  Google Scholar 

  2. Bonadonna G, Valagussa P (1981) Dose-response effect of adjuvant chemotherapy in breast cancer. N Engl J Med 304:10–15

    Article  PubMed  CAS  Google Scholar 

  3. Bonadonna G, Valagussa P, De Palo G (1981) The results of adjuvant chemotherapy in breast cancer are predominantly due to the hormonal change such therapy induces: The view against. In: Van Scoy-Mosher MB (ed) Controversies in medical oncology. G. K. Hall & Co., Boston (in press)

    Google Scholar 

  4. Bonadonna G, Valagussa P, Rossi A et al. (1978) Are surgical adjuvant trial altering the course of breast cancer? Semin Oncol 5:450—464

    PubMed  CAS  Google Scholar 

  5. Bonadonna G, Valagussa P, Tancini G, Di Fronzo G (1980) Estrogen-receptor status and response to chemotherapy in early and advanced breast cancer. Cancer Chemother Pharmacol 4: 37–41

    Article  PubMed  CAS  Google Scholar 

  6. Brambilla C, Valagussa P, Bonadonna G, Veronesi U (1980) Sequential adjuvant chemotherapy in postmenopausal (≤ 65 year) breast cancer. Proc Am Assoc Cancer Res 21: 189

    Google Scholar 

  7. Habs M, Schmahl D (1981) Carcinogenic activity of cyclophosphamide, methotrexate, 5-fluorouracil treatment in rats. Int J Cancer (in press)

    Google Scholar 

  8. Legha SS, Buzdar AU, Smith TL et al. (1979) Complete remissions in metastatic breast cancer treated with combination drug therapy. Ann Intern Med 91:847–852

    PubMed  CAS  Google Scholar 

  9. Lippman ME, Allegra JC, Thompson EB et al. (1978) The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N Engl J Med 298:1223–1228

    Article  PubMed  CAS  Google Scholar 

  10. Norton L, Simon R (1977) Tumor size, sensitivity to therapy and design of treatment schedules. Cancer Treat Rep 61:1307–1317

    PubMed  CAS  Google Scholar 

  11. Rossi A, Bonadonna G, Valagussa P, Veronesi U (1981) Multimodal treatment in operable breast cancer: 5-year results of the CMF program. Br Med J (in press)

    Google Scholar 

  12. Skipper HE (1980) Response of advanced breast cancer to CMF (cyclophosphamide, methotrexate, 5-fluorouracil). Birmingham, Ala., Southern Research Institute (Booklet 2)

    Google Scholar 

  13. Skipper HE (1980) Breast cancer treated by means of mastectomy and mastectomy followed by 12 or 6 cycles of CMF. Birmingham, Ala., Southern Research Institute (Booklet 4)

    Google Scholar 

  14. Steroid Receptors in Breast Cancer. An NIH Consensus Development Conference (1980) Bethesda, Maryland, June 27–29, 1979. Cancer 46:2759–2963

    Google Scholar 

  15. Tancini G, Bajetta E, Marchini S, Valagussa P, Bonadonna G, Veronesi U (1979) Preliminary 3-year results of 12 versus 6 cycles of surgical adjuvant CMF in premenopausal breast cancer. Cancer Clin Trials 2:285–292

    PubMed  CAS  Google Scholar 

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© 1982 Springer-Verlag Berlin · Heidelberg

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Bonadonna, G. et al. (1982). Multimodal Therapy with CMF in Resectable Breast Cancer with Positive Axillary Nodes: The Milan Institute Experience. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-81685-7_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81687-1

  • Online ISBN: 978-3-642-81685-7

  • eBook Packages: Springer Book Archive

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