Summary
Fourteen untreated patients with Ph1-positive chronic myeloid leukaemia received combination chemotherapy consisting of blocks of doxorubicin, vincristine, cytosine arabinoside and 6-thioguanine. Significant karyotypic conversion occurred in six patients, the percentage of Ph1-positive cells in the bone marrow falling by at least 50%. Maintenance therapy comprised vincristine, busulphan, hydroxyurea, 6-mer- captopurine and dibromannitol in rotation. Reinduction therapy was administered when Ph1 positivity reverted to 100%. Karyotypic reconversion was achieved in three of four patients. After induction, chromosme analysis of the bone marrow was performed every 3-6 months to detect the appearance of aneuploid clones, the intention being to intensify therapy at that stage.
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© 1982 Springer-Verlag Berlin · Heidelberg
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Sharp, J.C. (1982). Prevention of Blastic Crisis in Ph1-Positive Chronic Myeloid Leukemia. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_13
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DOI: https://doi.org/10.1007/978-3-642-81685-7_13
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