Methyl-CCNU and Ftorafur in Treatment of Rectosigmoidal Tumors and Ftorafur Capsules in Treatment of Colorectal Tumors

  • Z. Mechl
  • A. Malíř
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 79)

Abstract

Rectosigmoidal (RS) carcinoma in Czechoslovakia ranks among the important tumoral diseases due to its incidence and course. In 1975, a total of 1,949 new cases of malignant RS tumors were diagnosed; of these, 1,103 were in males, representing 6% of all male malignant tumors (incidence per 100,000 = 22.6). In females, 864 new cases were diagnosed, representing 5.1% of all female tumors (incidence per 100,000 = 16.3).

Keywords

Toxicity Cobalt Adenocarcinoma Oncol Diarrhea 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Belt RJ, Stephens R (1979) Phase I–II study of ftorafur and methyl-CCNU in advanced colorec tal cancer. Cancer 44: 869–872PubMedCrossRefGoogle Scholar
  2. 2.
    Brutti A, Liberati AM, Biscottini B (1979) Combination chemotherapy with 5-fluorouracil and methyl CCNU for the treatment of advanced gastrointestinal cancer. Tumori 65: 339–344PubMedGoogle Scholar
  3. 3.
    Diggs OH, Wiesnik PH, Smyth AC (1977) Methyl-CCNU and ftorafur with or without methanol extracted residue of BCG for metastatic adenocarcinoma of the colon. Cancer Treat Rep 61: 1581–1583PubMedGoogle Scholar
  4. 4.
    Hartwich G, Neidkardt B (1978) Chemotherapie kolorektaler Karzinome. Dtsch Med Wochenschr 103: 1463–1465PubMedCrossRefGoogle Scholar
  5. 5.
    Higgins G Jr, Humprey E, Juler GL (1976) Adjuvant chemotherapy in the surgical treatment of large bowel cancer. Cancer 38: 1461–1467PubMedCrossRefGoogle Scholar
  6. 6.
    Kemeny N, Yagoda A, Braun D Jr, Golbey R (1980) Therapy for metastatic colorectal carcinoma with a combination of methyl-CCNU, 5-fluorouracil, vincristine, and strepto- zotocin. Cancer 45: 876–881PubMedCrossRefGoogle Scholar
  7. 7.
    Lokich J, Skarin AT, Mayer RJ, Frei E (1977) Lack of effectiveness of combined 5-fluorouracil and methyl-CCNU therapy in advanced colorectal cancer. Cancer 40: 2792–2796PubMedCrossRefGoogle Scholar
  8. 8.
    Moertel CG, Schutt AJ, Hahn RG (1975) Therapy of advanced colorectal cancer with a combination of 5-fluorouracil, methyl-l,3-cis-(2-chloroethyl)-l-nitrosourea and vincristine. J Natl Cancer Inst 54: 69–71PubMedGoogle Scholar
  9. 9.
    Wooley PV, Macdonald JS, Schein PD (1960) Chemotherapy of colorectal carcinoma. Semin Oncol 3: 415–420Google Scholar
  10. 10.
    Toxicology of ftorafur in capsules (1979) Ftorafur, an antitumor drug. Inst, of Organic Synthesis, Latvian SSR Academy of Sciences, Riga. Instituts-VerlagGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Z. Mechl
    • 1
  • A. Malíř
    • 1
  1. 1.Clinical and Experimental OncologyCancer Research InstituteBrnoCzechoslovakia

Personalised recommendations