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Why Do Colon Tumours Respond Poorly to Chemotherapeutic Agents?

  • Chapter
Chemotherapy and Radiotherapy of Gastrointestinal Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 79))

Abstract

In theory any of the following mechanisms, singly or in combination, may form the basis of a poor response to cytostatic agents:

  1. a)

    Inherent cellular insensitivity to cytostatic drugs

  2. b)

    Inhomogeneity in drug sensitivity among tumours of a certain type

  3. c)

    Few proliferating cells in each tumour, since proliferating cells respond better to drugs

  4. d)

    Poor vascularization of the tumour preventing the cytostatic drugs from reaching the tumour cells

  5. e)

    Early emergence of a drug-resistant cell line after exposure to each agent

  6. f)

    Surviving tumour cells proliferating rapidly during treatment.

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Author information

Authors and Affiliations

  1. Radiobiological Institute TNO, P.O. Box 5815, NL-2280 HV, Rijswijk, The Netherlands

    L. M. van Putten, E. A. Sluijter, T. Smink & J. H. Mulder

Authors
  1. L. M. van Putten
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  2. E. A. Sluijter
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  3. T. Smink
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  4. J. H. Mulder
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Editor information

Editors and Affiliations

  1. Medizinische Universitätsklinik, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Germany

    Hans Otto Klein

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© 1981 Springer-Verlag Berlin Heidelberg

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van Putten, L.M., Sluijter, E.A., Smink, T., Mulder, J.H. (1981). Why Do Colon Tumours Respond Poorly to Chemotherapeutic Agents?. In: Klein, H.O. (eds) Chemotherapy and Radiotherapy of Gastrointestinal Tumors. Recent Results in Cancer Research, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81681-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-81681-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81683-3

  • Online ISBN: 978-3-642-81681-9

  • eBook Packages: Springer Book Archive

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