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Pathologische Anatomie oraler Aphthosen

  • Conference paper
XXXII. Tagung gehalten in Westerland/Sylt vom 16. bis 20. September 1980

Part of the book series: Verhandlungen der Deutschen Dermatologischen Gesellschaft ((VDGDERMATOLOGIE,volume 32))

Zusammenfassung

Aphthosen sind rezidivierend auftretende, solitäre oder multiple entzündliche Epitheldefekte der Mundschleimhaut (Hornstein 1976). Man unterscheidet milde und schwere Formen. Sie können als benigne Form im wesentlichen auf die Mundschleimhaut beschränkt bleiben, oder aber als sog. maligne Aphthose mit generalisierten Krankheitserscheinungen einhergehen. Letztere Form wird — besonders in ihrer typischen Ausprägung mit Ulzeration im Genitalbereich und rezidivierender Iridozyklitis — als Morbus Behçet bezeichnet.

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Literatur

  1. Akkaynak S, Enacar N, Cobanli B, Ayas G, Ortakaya M, Imecik O, Hacihabioglu G, Yücel K (1979) Behçet’s disease and lungs. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease pp 160–162

    Google Scholar 

  2. Alemà G, Bignami A (1979) Involvement of the nervous system in Behçet’s disease. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford pp 52–66

    Google Scholar 

  3. Bernhard GC, Goldman AL, Kozin F, Heim LR (1979) Further observations on the treatment of Behçet’s syndrome with transfer factor. In: Dilsen N, Koniçe, M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 293–300

    Google Scholar 

  4. Beroniade V (1975) Amyloidosis and Behçet’s disease. Ann Intern Med 83: 904–905

    PubMed  CAS  Google Scholar 

  5. Bietti GB, Bruna F (1966) An ophthalmic report on Behçet’s disease. In: Monacelli M, Nazzaro P (eds) Behçet’s disease. Karger, Basel pp 79–110

    Google Scholar 

  6. Bonamour G, Grange JD, Bonnet M (1979) Retinal vain involvement in Behçet’s disease. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 142–144

    Google Scholar 

  7. Brody HA, Silverman S (1969) Studies on recurrent oral aphthae. I. Clinical and laboratory comparisons. Oral Surg 27: 27–34

    Article  PubMed  CAS  Google Scholar 

  8. Burkhardt A (1980) Der Mundhöhlenkrebs and seine Vorstadien. Fischer, Stuttgart

    Google Scholar 

  9. Cabre J, Brehm G (1964) Histologische and immunbiologische Untersuchungen zum Behçet-Syndrom. Dermatol Wochenschr 150: 566

    PubMed  CAS  Google Scholar 

  10. Cohen L (1978) Etiology, pathogenesis and classification of aphthous stomatitis and Behçet’s syndrome. J Oral Pathol 7: 347–352

    Article  PubMed  CAS  Google Scholar 

  11. Colmant H-J, Hansen J, Knipp HP (1973) Akute Enzephalitis bei Morbus Behçet. Schweiz Arch Neurol Neurochir Psychiatr 113: 227–243

    PubMed  CAS  Google Scholar 

  12. Cooke BED (1961) Recurrent Mikulicz’s aphthae. Dent Pract 12: 119–124

    Google Scholar 

  13. Dilsen N, Koniçe M, Erbengi T, Ovül C, Berker F, Aral O, Urgancioglu M, Ozdogan E (1979) Amyloidosis in two cases of Behçet’s disease. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 171–175

    Google Scholar 

  14. Dodson MG, Klegerman ME, Kerman RH, Lange CF, Tessler HH, O’Leary JA (1978) Behçet’s syndrome: with immunologic evaluation. Obstet Gynecol 51: 621–625

    Article  PubMed  CAS  Google Scholar 

  15. Dolby AE (1969) Recurrent aphthous ulceration. Effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells. Immunology 17: 709–714

    PubMed  CAS  Google Scholar 

  16. Donatzky O (1976) A leukocyte migration study on the cell-mediated immunity against adult human oral mucosa and streptococcal antigens in patients with recurrent aphthous stomatitis. Acta Pathol Microbiol Scand 84: 227–234

    Google Scholar 

  17. Donatzky O (1978) Cell-mediated and humoral immunity against oral streptococci, neisseria, staphylococci, and adult human oral mucosa antigens in recurrent aphthous stomatitis. Scand J Dent Res 86: 25–34

    Google Scholar 

  18. Donatzky O, Dabelsteen E (1974) An immunofluorescente study on the humoral immunity to adult humal oral mucosa in recurrent aphthous stomatitis. Acta Allergol (Copenh) 29: 308–318

    Google Scholar 

  19. Francis TC (1970) Recurrent aphthous stomatitis and Behçet’s disease. A review. Oral Surg 30: 476–486

    Article  PubMed  CAS  Google Scholar 

  20. Fröscher W, Meyer-Lindenberg J, Schlieter F, Gullota F, Bechtelsheimer H (1973) Klinisch-morphologische Befunde beim Morbus Behçet. Dtsch Med Wochenschr 98: 105–109

    Article  PubMed  Google Scholar 

  21. Fukuda Y, Watanabe I (1979) Pathological studies on intestinal Behçet’s (Entero-Behçet’s) disease. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 90–95

    Google Scholar 

  22. Gamble CN, Wiesner KB, Shapiro RF (1979) The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet’s disease. Am J Med 66: 1031–1039

    Article  PubMed  CAS  Google Scholar 

  23. Gilbert W (1925) Über chronische Verlaufsform der meta-statischen Ophthalmia („Ophthalmia lenta“). Arch Augenheilk 96: 119–130

    Google Scholar 

  24. Graykowski EA, Barile MF, Lee WB, Stanley HR (1966) Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic and hypersensitivity aspects. 196: 637–644

    CAS  Google Scholar 

  25. Haim S (1979) The pathogenesis of lesions in Behçet’s disease. Dermatologica 158: 31–37

    Article  PubMed  CAS  Google Scholar 

  26. Herrmann D (1970) Zur Morphogenese der chronisch-recidivierenden Aphthen. Dtsch Zahnaerztl Z 25: 993–999

    PubMed  CAS  Google Scholar 

  27. Honma T (1976) Electron microscopic study on the pathogenesis of recurrent aphthous ulceration as comapred to Behçet’s syndrome. Oral Surg 41: 366–377

    Article  PubMed  CAS  Google Scholar 

  28. Hornstein OP (1972) Ist die Aphthosis Neumann eine nosologische Einheit? Z Haut Geschlechtskr 47: 787–792

    PubMed  CAS  Google Scholar 

  29. Hornstein OP (1976) Entzündliche and systemische Reaktionen in der Mundschleimhaut. Arch Oto Rhino Laryngol 213: 287–331

    Article  CAS  Google Scholar 

  30. Kaneko H, Nakajima H, Okamura A, Fuase M, Katano A, Hojo H, Ishikawa S (1976) Histopathology of Behçet’s disease. Review of the literature with a case report. Acta Pathol Jpn 26: 765–779

    PubMed  CAS  Google Scholar 

  31. Kansu E, Deglin S, Cantor RJ, Burke JF, Sho SY, Cathart RT (1977) The expanding spectrum of Behçet’s syndrome: a case with renal involvement. JAMA 237: 1855–1856

    Article  PubMed  CAS  Google Scholar 

  32. Lehmann H, Stutte HJ, Zierott G, Schlaak M (1975) Morbus Behçet und multiple intestinale Ulzerationen. Dtsch Med Wochenschr 100: 308–311

    Article  PubMed  CAS  Google Scholar 

  33. Lehner T (1968) Autoimmunity in oral diseases with special reference to recurrent oral ulceration. Proc R Soc Med 61: 515–524

    PubMed  CAS  Google Scholar 

  34. Lehner T (1969) Pathology of recurrent oral ulcerations and ulcerations in Behçet’s syndrome: electron and fluorescence microscopy. J Pathol 97: 481–494

    Article  PubMed  CAS  Google Scholar 

  35. Lehner T (1977) Oral ulceration and Behçet’s syndrome. Gut 18: 491–511

    Article  PubMed  CAS  Google Scholar 

  36. Lehner T (1978) Immunological aspects of recurrent oral ulceration and Behçet’s syndrome. J Oral Pathol 7: 424–430

    Article  PubMed  CAS  Google Scholar 

  37. Lehner T (1979) Immuno-pathology of Behçet’s syndrome. In: Lehner T (ed) Behçet’s syndrome. Acadmic Press, London New York Toronto Syndney San Francisco

    Google Scholar 

  38. Lehner T, Sagebiel RW (1966) Fine structural findings in recurrent oral ulceration. Br Dent J 121: 454–456

    PubMed  CAS  Google Scholar 

  39. Levinsky RJ, Lehner T (1978) Circulating soluble immune complexes in recurrent oral ulceration and Behçet’s syndrome. Clin Exp Immunol 32: 193

    PubMed  CAS  Google Scholar 

  40. Lichtig C, Haim S, Hammel I, Friedman-Birnbaum R (1980) The quantification and significance of mast cells in lesions of Behçet’s disease. Br J Dermatol 102: 255–259

    Article  PubMed  CAS  Google Scholar 

  41. Luzardo-Baptista MJ (1975) Aspects of the fine anatomy of aphthous stomatitis. Oral Surg 39: 239–248

    Article  PubMed  CAS  Google Scholar 

  42. Maciejewski W, Bandmann HJ (1979) Immune complex vasculitis in a patient with Behçet’s syndrome. Arch Dermatol Res 264: 253–256

    Article  PubMed  CAS  Google Scholar 

  43. Moeschlin S (1969) Klinische Demonstration neurologischer Fälle. Schweiz Med Wochenschr 99: 1632–1640

    PubMed  CAS  Google Scholar 

  44. Monteleone L (1967) Periadenitis mucosae necroticans recurrens. Oral Surg 23: 586–590

    Article  PubMed  CAS  Google Scholar 

  45. Nazzaro P (1966) Cutaneous manifestations of Behçet’s disease. In: Monacelli M, Nazzaro P (eds) Behçet’s disease. Karger, Basel, pp 15–41

    Google Scholar 

  46. Nicholas KC, Bays RA, Lyon ED (1975) Periadenitis mucosa necrotica recurrens. J Oral Surg 33: 65–70

    PubMed  CAS  Google Scholar 

  47. Norman RM, Campbell AMG (1979) The neuropathology of Behçet’s disease. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 67–78

    Google Scholar 

  48. Noyan B, Aktin E, Tangör A, Özcan H (1979) A post-mortem study on a case of Behçet’s disease affecting the central nervous system and the other organs. In: Dilsen N, Koniçe M, Ovül C (eds) Behçet’s disease. Excerpta Medica, Amsterdam Oxford, pp 99–103

    Google Scholar 

  49. Rogers RS (1977) Recurrent aphthous stomatitis: clinical characteristics and evidence for an immunopathogenesis. J Invest Dermatol 69: 499–509

    Article  PubMed  Google Scholar 

  50. Rogers RS, Sams WM, Shorter RG (1974) Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Behçet syndrome. Arch Dermatol 109: 361–363

    Article  PubMed  Google Scholar 

  51. Rosenthal T, Bank H, Aladjem M, Davis R, Gafni J (1975) Systemic amyloidosis in Behçet’s disease. Ann Intern Med 83: 220–223

    PubMed  CAS  Google Scholar 

  52. Rougier M, Kuffer R, Laugier P (1979) L’aphthose. Praxis 68: 298–306

    CAS  Google Scholar 

  53. Saito T, Honma T, Sato T, Fujioka Y (1971) Auto-immune mechanisms as a probable aetiology of Behçet’s syndrome, an electron microscopic study of the oral mucosa. Virchows Arch [Pathol Anat] 353: 261–272

    Article  CAS  Google Scholar 

  54. Shikano S (1966) Ocular pathology of Behçet’s syndrome. In: Monacelli M, Nazzaro P (eds) Behçet’s disease. Karger, Basel, pp 111–136

    Google Scholar 

  55. Smith GE, Kime LR, Pitcher JL (1973) The colitis of Behçet’s disease: a separate entity? Colonoscopic findings of literature review. Am J Dig Dis 18: 987–1000

    Article  PubMed  CAS  Google Scholar 

  56. Stanley HR (1972) Aphthous lesions. Oral Surg 33: 407–416

    Article  PubMed  CAS  Google Scholar 

  57. Stenman G, Heyden G (1980) Premonitory stages of recurrent aphthous stomatitis. I. Histological and enzyme histochemical investigations. J Oral Pathol 9: 155–162

    Article  PubMed  CAS  Google Scholar 

  58. Sulheim O, Dalgaard JB, Ry Andersen S (1959) Behçet’s syndrome: report of a case with complete autopsy performed. Acta Pathol Microbiol Scand 45: 145–158

    Article  Google Scholar 

  59. Tennstedt A (1978) Zur Kenntnis des Morbus Behçet (ophthalmo-meningo-enzephale Variante). Zentralbl Allg Pathol 122: 87–99

    PubMed  CAS  Google Scholar 

  60. Thach BT, Cumming NA (1976) Behçet’s syndrome with aphthous colitis. Arch Intern Med 136: 705–709

    Article  PubMed  CAS  Google Scholar 

  61. Vernon-Roberts B, Barnes CG, Revell PA (1978) Synovial pathology in Behçet’s syndrome. Ann Rheum Dis 37: 139–145

    Article  PubMed  CAS  Google Scholar 

  62. Eilgram GF (1972) A possible role of the Merkel cell in aphthous stomatitis. Oral Surg 34: 231–238

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Pathologisches Institut der Universität Bern, Freiburgstrasse 30, CH-3010, Bern, Schweiz

    Arne Burkhardt

  2. Institut für Pathologie der Universität Hamburg, Hamburg, Deutschland

    T. Löning

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  1. Arne Burkhardt
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  2. T. Löning
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Editors and Affiliations

  1. Universitäts-Hautklinik, Schittenhelmstraße 7, D-2300, Kiel, Deutschland

    E. Christophers (Tagungsleiter) & M. Goos (Tagungssekretär) (Tagungsleiter) &  (Tagungssekretär)

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© 1981 Springer-Verlag Berlin Heidelberg

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Burkhardt, A., Löning, T. (1981). Pathologische Anatomie oraler Aphthosen. In: Christophers, E., Goos, M. (eds) XXXII. Tagung gehalten in Westerland/Sylt vom 16. bis 20. September 1980. Verhandlungen der Deutschen Dermatologischen Gesellschaft, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81671-0_92

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  • DOI: https://doi.org/10.1007/978-3-642-81671-0_92

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10909-9

  • Online ISBN: 978-3-642-81671-0

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