Effektorzellen der anaphylaktischen Reaktion

  • B. M. Czarnetzki
Conference paper
Part of the Verhandlungen der Deutschen Dermatologischen Gesellschaft book series (VDGDERMATOLOGIE, volume 32)

Zusammenfassung

Während Makrophagen und T- und B-Lymphozyten für die Stimulierung und Regulierung der IgE-spezifischen Immunreaktion verantwortlich sind, fällt die eigentliche Effektorfunktion im akuten allergischen Geschehen der Gewebemastzelle und dem dieser Zelle sehr ähnlichen Blutbasophilen zu. Beide Zellen können innerhalb von Sekunden nach einer spezifischen Stimulierung verschiedene Vermittlersubstanzen freilassen, worauf es lokal oder im gesamten Organismus zu massiven Veränderungen kommt. Durch Einwirken dieser primären Mediatoren können weitere Effektorzellen, hauptsächlich eosinophile und neutrophile Zellen, zu Hilfe gerufen werden und den Ablauf der Entzündungsreaktionen durch Mediatoren und modulierende Substanzen entscheidend verändern. Diese Zellen und die komplexen Vorgänge, die durch sie verursacht werden, sollen hier anhand neuerer Befunde diskutiert werden, um auf diese Weise den klinischen Ablauf der akuten allergischen Reaktion verständlicher werden zu lassen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • B. M. Czarnetzki
    • 1
  1. 1.Universitäts-HautklinikMünsterDeutschland

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