The Nature of ACTH-Related Peptides in Cushing’s Disease and Syndrome

  • Dorothy T. Krieger
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 22)


The nature of ACTH and related peptides present in and secreted from normal anterior pituitary has been discussed in Chap. 1. As noted, the 1–39 form of ACTH is the predominant form identified in the pituitary, except for a variable fraction (previously termed big ACTH) eluting in the void volume, which represents approximately 15 %–25 % of the total ACTH content (Gewirtz and Yalow 1974; Orth and Nicholson 1977). Since at the time of these studies the extent of cross-reactivity of available antibodies with pro-opiocortin was not known, the actual amount of precursor present cannot be definitively stated.


Normal Pituitary Ectopic ACTH Syndrome High Molecular Weight Material Plasma ACTH Concentration Ectopic Tumor 
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  1. Bertagna X, Ferard F, Seurier D, Luton JP, Bricaire H, Main ER, Eipper BE (1980) Evidence for a peptide similar to 16K fragment in man: Its relationship to ACTH. J Clin Endocrinol Metab 51:182–184PubMedCrossRefGoogle Scholar
  2. Bertagna XY, Nicholson WE, Tanaka K, Mount CD, Sorenson GD, Pettengil OS, Orth DN (1979) Ectopic production of ACTH, lipotropin, and β-endorphin by human cancer celtø. Structurally related tumor markers. Recent Results Cancer Res 67:16–25Google Scholar
  3. Gewirtz G, Yalow RS (1974) Ectopic ACTH production in carcinoma of the lung. J Clin Invest 53:1022–1032PubMedCrossRefGoogle Scholar
  4. Harata Y, Matsukura S, Imura H, Nakamura M, Tanaka A (1976) Size heterogeneity of jß-MSH in ectopic ACTH-producing tumors: Presence of β-LPH-like peptide. J Clin Endocrinol Metab 42:33–40CrossRefGoogle Scholar
  5. Hashimoto K, Takahara J, Ogawa N, Yunoki S, Ofuji T, Arata A, Kanda S, Terada K (1980) Adrenocorticotropic β-lipotropin, β-endorphin, and corticotropin-releasing factor-like activity in an adrenocorticotropin-producing nephroblastoma. J Clin Endocrinol Metab 50:461–465PubMedCrossRefGoogle Scholar
  6. Himsworth RL, Bloomfield GA, Coombes RC, Ellison M, Gilkes JJH, Lowry PJ, Setchell KDR, Slavin G, Rees LH (1977) ‘Big ACTH’ and calcitonin in an ectopic hormone-secreting tumour of the liver. Clin Endocrinol 7:45–62CrossRefGoogle Scholar
  7. Krieger DT, Choi HH, Anderson PJ (1976) The characterization of the ACTH produced by a primary pituitary tumour in a patient with Cushing’s disease. Clin Endocrinol 5:455–472CrossRefGoogle Scholar
  8. Liotta A, Krieger DT (1980) In vitro biosynthesis and comparative posttranslational processing of immunoreactive precursor corticotropin/ β-endorphin by human placental and pituitary cells. Endocrinology (in press)Google Scholar
  9. Liotta AS, Suda T, Krieger DT (1978) β-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: Lack of significant β-endorphin. Proc Nat Acad Sci USA 75:2950–2954PubMedCrossRefGoogle Scholar
  10. Lowry PJ, Silman RE, Hope J (1977) Structure and biosynthesis of peptides related to corticotropins and β-rnelanotropins. Ann NY Acad Sci 297:49–62PubMedCrossRefGoogle Scholar
  11. Nakai Y, Tanaka I, Fukata J, Nakao K, Oki S, Takai S, Imura H (1980) Evidence for gamma-MSH-like immunoreactivity in ectopic ACTH-producing tumors. J Clin Endocrinol Metab 50:1147–1148PubMedCrossRefGoogle Scholar
  12. Nichols J, Gourley W (1963) Adrenal weight-maintaining corticotropin in carcinoma of the lung. JAMA. 185:68–70Google Scholar
  13. Orth DN, Nicholson WE (1977) Different molecular forms of ACTH. In: Krieger DT, Ganong WF (eds) ACTH and related peptides: Structure regulation and action. Ann NY Acad Sei 297:27–46Google Scholar
  14. Orth DN, Nicholson WE, Mitchell WM, Island DP, Liddle GW (1973) Biological and immunological characterization and physical separation of ACTH and ACTH fragments in the ectopic ACTH syndrome. J Clin Invest 52:1756–1759PubMedCrossRefGoogle Scholar
  15. Pullan PT, Ratter SJ, McLouglin L, Clement-Jones V, Lowry PJ, Besser SM, Rees LH (1980) Adrenocorticotrophin, lipotrophin and opioid peptides in the ectopic ACTH syndrome. VI International Congress Endocrinology, Melbourne, 761 (Abstract)Google Scholar
  16. Ratcliffe JG, Knight RA, Besser GM, Landon J, Stansfeld AG (1972) Tumor and plasma ACTH concentrations in patients with and without the ectopic ACTH syndrome. Clin Endocrinol 1:27–44CrossRefGoogle Scholar
  17. Rees LH, Ratcliffe JG (1974) Ectopic hormone production by non-endocrine tumors. Clin Endocrinol 3:263–302CrossRefGoogle Scholar
  18. Scott AP, Lowry PJ (1974) Adrenocorticotropic and melanocyte-stimulating peptides in the human pituitary. Biochem J 139:593–602PubMedGoogle Scholar
  19. Suda T, Abe Y, Demura H, Demura R, Shizume K, Tamahashi N, Sasano N (1979) ACTH, β-LPH and β-endorphin in pituitary adenomas of the patients with Cushing’s disease: Activation of β-LPH conversion to β-endorphin. J Clin Endocrinol Metab 49:475–477PubMedCrossRefGoogle Scholar
  20. Tanaka K, Nicholson WE, Orth DN (1978) The nature of the immunoreactive lipotropins in human plasma and tissue extracts. J Clin Invest 62:94–104PubMedCrossRefGoogle Scholar
  21. Wolfsen AR, Odell WD (1979) Pro ACTH: Use for early detection of lung cancer. Am J Med 66:765–772PubMedCrossRefGoogle Scholar
  22. Yalow RS (1979) Big ACTH and bronchogenic carcinoma. Ann Rev Med 30:241–248PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1982

Authors and Affiliations

  • Dorothy T. Krieger
    • 1
  1. 1.Division of EndocrinologyThe Mount Sinai Medical CenterNew YorkUSA

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