The Nature of ACTH-Related Peptides in Cushing’s Disease and Syndrome
The nature of ACTH and related peptides present in and secreted from normal anterior pituitary has been discussed in Chap. 1. As noted, the 1–39 form of ACTH is the predominant form identified in the pituitary, except for a variable fraction (previously termed big ACTH) eluting in the void volume, which represents approximately 15 %–25 % of the total ACTH content (Gewirtz and Yalow 1974; Orth and Nicholson 1977). Since at the time of these studies the extent of cross-reactivity of available antibodies with pro-opiocortin was not known, the actual amount of precursor present cannot be definitively stated.
KeywordsNormal Pituitary Ectopic ACTH Syndrome High Molecular Weight Material Plasma ACTH Concentration Ectopic Tumor
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