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Auto-immunity in Diabetes Mellitus

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Auto-immunity in the Endocrine System

Part of the book series: Monographs on Endocrinology ((ENDOCRINOLOGY,volume 20))

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Abstract

Diabetes mellitus was a disease known to the ancients (Best 1960). Symptoms of this disorder were first described in the Ebers papyrus of Egypt (1500 B. C.). Aretaeus of Cappadocas termed the disorder diabetes in the second century A. D. The Greek word “diabetes” means “to flow through a siphon”. The more recent history of diabetes mellitus constitutes a fascinating story in its own right, culminating in the discovery of insulin by Banting and Best of Toronto in 1921 (Banting and Best 1922) and was summarized by Best in 1960. The current chapter, however, will deal primarily with immune aspects of the disorder, and will not delve further into the metabolic, vascular and other protean aspects of this important malady.

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References

  • Adams SF (1926) The seasonal variation in the onset of acute diabetes; the age and sex factor in 1000 diabetic patients. Arch Intern Med 37: 861–864

    Article  Google Scholar 

  • Andersen OO (1976) Anti-insulin antibodies and late diabetic complications. Acta Endocrinol (Copenh) 83: 329–340

    CAS  Google Scholar 

  • Andersen OO, Nerup J, Bendixen G, Egeberg J, Gunnarsson R, Kromann H, Poulsen JE (1974) Experimental induction of anti-pancreatic cell-mediated immunity associated with B-cell degeneration and glucose intolerance in rodents. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 211–217

    Google Scholar 

  • Anderson JH, Blackard WG, Goldman J, Rubinstein AH (1978) Diabetes and hypoglycaemia due to insulin antibodies. Am J Med 64: 868–873

    Article  PubMed  Google Scholar 

  • Arquilla ER, Michalski RE, Roth MD (1980) Involvement of cell-mediated immunity in chronic alloxan diabetic mice (Abstract 206). Diabetes [Suppl 2]29: 52A

    Google Scholar 

  • Bagdade JD, Root RK, Bulger RJ (1974) Impaired leucocyte function in patients with poorly controlled diabetes. Diabetes 23: 9–15

    PubMed  CAS  Google Scholar 

  • Banting FG, Best CH (1922) Pancreatic extracts. J Lab Clin Med 7: 464–472

    CAS  Google Scholar 

  • Barbosa J, King R, Noreen H, Yunis EJ (1977) The histocompatibility system in juvenile, insulin-dependent diabetic multiple kindreds. J Clin Invest 60: 989–998

    Article  PubMed  CAS  Google Scholar 

  • Bates G, Weiss C (1941) Delayed development of antibody to Staphylococcus toxin in diabetic children. Am J Dis Child 62: 346–351

    Google Scholar 

  • Berson SA, Yalow RS (1959 a) Recent studies on insulin-binding antibodies. Ann NY Acad Sci 82: 338–344

    Article  CAS  Google Scholar 

  • Berson SA, Yalow RS (1959 b) Quantitative aspects of the reaction between insulin and insulinbinding antibody. J Clin Invest 38: 1996–2016

    Article  CAS  Google Scholar 

  • Berson SA, Yalow RS (1961) Preparation and purification of human insulin-I131; binding to human insulin-binding antibodies. J Clin Invest 40: 1803–1808

    Article  PubMed  CAS  Google Scholar 

  • Berson SA, Yalow RS, Bauman A, Rothschild MA, Newerly K (1956) Insulin 31 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects. J Clin Invest 35: 170–190

    Article  PubMed  CAS  Google Scholar 

  • Best CH (1960) Epochs in the history of diabetes. In: Williams RH (ed) Diabetes. Hoeber, New York, pp 1–13

    Google Scholar 

  • Bloom A, Hayes TM, Gamble DR (1975) Register of newly diagnosed diabetic children. Br Med J 3: 580–583

    Article  PubMed  CAS  Google Scholar 

  • Bottazzo GF, Doniach D (1978) Islet cell antibodies (ICA) in diabetes mellitus. Evidence of an autoantigen common to all cells in the islets of Langerhans. Ric Clin Lab 8: 29–38

    PubMed  CAS  Google Scholar 

  • Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2: 1279–1283

    Article  PubMed  CAS  Google Scholar 

  • Bottazzo, GF, Cudworth AG, Moul DJ, Doniach D, Festenstein H (1978 a) Evidence for a primary autoimmune type of diabetes mellitus (type Ib). Br Med J 2: 1253–1255

    Article  CAS  Google Scholar 

  • Bottazzo GF, Mann JI, Thorogood M, Baum JD, Doniach D (1978 b) Autoimmunity in juvenile diabetics and their families. Br Med J 2: 165–168

    Google Scholar 

  • Bottazzo GF, Dean BM, Gorsuch AN, Cudworth AG, Doniach D (1980) Complement fixing islet-cell antibodies in type I diabetes: possible monitors of active beta cell damage. Lancet 1: 668–672

    PubMed  CAS  Google Scholar 

  • Brown J (ed) (1980) Proceedings of a conference on pancreas transplantation, June 8–9 1979 Diabetes 29 (Suppl 1) 1–128

    Google Scholar 

  • Burkholder PM (1965) Immunohistopathologic study of localized plasma proteins and fixation of guinea pig complement in renal lesions of diabetic glomerulosclerosis. Diabetes 14: 755–770

    PubMed  CAS  Google Scholar 

  • Buschard K, Rygaard J (1977) Passive transfer of streptozotocin induced diabetes mellitus with spleen cells. Acta Pathol Microbiol Scand [C] 85:469–472

    Google Scholar 

  • Buschard K, Rygaard J (1978) Is the diabetogenic effect of streptozotocin in part thymus dependent? Acta Path Microbiol Scand [C] 86: 23–27

    CAS  Google Scholar 

  • Buschard K, Madsbad S, Rygaard J (1978) Passive transfer of diabetes mellitus from man to mouse. Lancet 1: 908–910

    Article  PubMed  CAS  Google Scholar 

  • Buschard K, Madsbad S, Rygaard J (1980) Depressed suppressor cell activity in patients with newly diagnosed insulin-dependent diabetes mellitus. Clin Exp Immunol 41: 25–32

    PubMed  CAS  Google Scholar 

  • Christy M, Nerup J, Bottazzo GF, Doniach D, Platz P, Svejgaard A, Ryder LP, Thomsen M (1976) Association between HLA-B8 and autoimmunity in juvenile diabetes mellitus. Lancet 2: 142–143

    Article  PubMed  CAS  Google Scholar 

  • Churg J, Dolger H (1971) Diabetic renal disease. In: Strauss MB, Welt LG (eds) Diseases of the kidney 2nd ed. Little Brown, Boston, pp 873–889

    Google Scholar 

  • Coleman SL, Becker B, Canaan S, Rosenbaum L (1962) Fluorescent insulin staining of the diabetic eye. Diabetes 11: 375–377

    PubMed  CAS  Google Scholar 

  • Craighead JE (1972) Inflammatory lesions of the islets of Langerhans. In: Greep RO, Astwood EB, Steiner DR, Frienkel N, Geiger SE (eds) Handbook of physiology, vol 1/7. American Physiological Society, Washington DC, pp 315–321

    Google Scholar 

  • Craighead JE (1974) Insulitis associated with viral infection. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 227–233

    Google Scholar 

  • Craighead JE (1978) Current views on the etiology of insulin-dependent diabetes mellitus. N Engl J Med 299: 1439–1445

    Article  PubMed  CAS  Google Scholar 

  • Craighead JE, McLane MF (1968) Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science 162: 913–914

    Article  PubMed  CAS  Google Scholar 

  • Craighead JE, Steinke J (1971) Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. Am J Pathol 63: 119–134

    PubMed  CAS  Google Scholar 

  • Cudworth AG (1976) The aetiology of diabetes mellitus. Br J Hosp Med 16: 207–216

    Google Scholar 

  • Cudworth AG (1977) The aetiology of diabetes. In: Besser M (ed) Advanced medicine, vol 13. Pitman, London, pp 163–172

    Google Scholar 

  • Cudworth AG (1978) Type I diabetes mellitus. Diabetologia 14: 281–291

    Article  PubMed  CAS  Google Scholar 

  • Cudworth AG, Gamble DR, White GSB, Lendrum R, Woodrow JC, Bloom A (1977) Aetiology of juvenile onset diabetes: a prospective study. Lancet 1: 385–388

    Article  PubMed  CAS  Google Scholar 

  • Deckert T, Egeberg J, Frimoldt-Moller C, Sander E, Svejgaard A (1979) Basement membrane thickness, insulin antibodies and HLA antigens in long standing insulin-dependent diabetics with and without severe retinopathy. Diabetologia 17: 91–96

    Article  PubMed  CAS  Google Scholar 

  • Doniach D, Bottazzo GF (1977) Autoimmunity in the endocrine pancreas. In: Joachim HL (ed) Pathobiology annual. Appleton-Century Crofts, New York, pp 327–346

    Google Scholar 

  • Doniach D, Bottazzo GF (1981) Viruses, autoimmunity, genes and receptors in diabetes. In: Bajaj JS (ed) Insulin and metabolism. Elsevier/North Holland, New York

    Google Scholar 

  • Drash AL (1979) The etiology of diabetes mellitus. N Engl J Med 300: 1211–1313

    Article  PubMed  CAS  Google Scholar 

  • Dumm ME (1957) Glucose utilization and lactate production by leukocytes of patients with diabetes mellitus. Proc Soc Exp Biol Med 95: 571–574

    PubMed  CAS  Google Scholar 

  • Esmann V (1964) Effect of cell concentration on the metabolism of normal and diabetic leukocytes in vitro. Metabolism 13: 354–360

    Article  PubMed  CAS  Google Scholar 

  • Fairchild RS, Kyner JL, Abdou NI (1980) Suppressor cell dysfunction in insulin dependent diabetes (Abstract 208). Diabetes [Supple. 2] 29:52 A

    Google Scholar 

  • Fajans SS, Cloutier MC, Crowther RL (1978) Clinical and etiologic heterogeneity of idiopathic diabetes mellitus. Diabetes 27: 1112–1125

    PubMed  CAS  Google Scholar 

  • Feldman R, Grodsky GM, Kohout FW, McWilliams NB (1963) Immunologic studies in a diabetic subject resistant to bovine insulin but sensitive to porcine insulin. Am J Med 35: 411–417

    Article  PubMed  CAS  Google Scholar 

  • Fialkow PJ, Zavala C, Nielsen R (1975) Thyroid autoimmunity: increased frequency in relatives of insulin-dependent diabetes patients. Ann Intern Med 83: 170–176

    PubMed  CAS  Google Scholar 

  • Flier JS, Kahn CR, Roth J (1979) Receptors, antireceptor antibodies and mechanism of insulin resistance. N Engl J Med 300: 413–419

    Article  PubMed  CAS  Google Scholar 

  • Foiling I, Norman N (1972) Hyperglycemia, hypoglycemic attacks and production of anti-insulin antibodies without previous known immunization; immunological and functional studies in a patient. Diabetes 21: 814–826

    Google Scholar 

  • Freedman P, Peters JH, Kark RM (1960) Localization of gamma-globulin in the diseased kidney. Arch Intern Med 105: 524–535

    Article  PubMed  CAS  Google Scholar 

  • Freytag G (1974) Do viruses serve as mediators of immunological reactions? In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam pp 247–251

    Google Scholar 

  • Friedman JM, Fialkow PJ (1978) The genetics of Graves’ disease. Clin Endocrinol Metab 7: 47–65

    Article  PubMed  CAS  Google Scholar 

  • From GLA, Craighead JE, McLane MF, Steinke J (1968) Virus-induced diabetes in mice. Metabolism 17: 1154–1158

    Article  PubMed  CAS  Google Scholar 

  • Galbraith RM (1979) Immunological aspects of diabetes mellitus. CRC, Boca Raton

    Google Scholar 

  • Gamble DR, Taylor KW (1969) Seasonal incidence of diabetes mellitus. Br Med J 3: 627–630

    Article  PubMed  CAS  Google Scholar 

  • Gamble DR, Kinsley ML, Fitzgerald MG, Bolton R, Taylor KW (1969) Viral antibodies in diabetes mellitus. Br Med J 3: 627–630

    Article  PubMed  CAS  Google Scholar 

  • Gamble DR, Taylor KW, Cumming H (1973) Coxsackie viruses and diabetes mellitus. Br Med J 4: 260–262

    Article  PubMed  CAS  Google Scholar 

  • Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619–633

    PubMed  CAS  Google Scholar 

  • Ginsberg-Fellner F, Dobersen M, Mark EM, Nechemias C, Hausknecht RU, Rubinstein P, Notkins AL (1980) Islet cell antibodies in gestational diabetes mellitus: prognostic value (Abstract 211). Diabetes [Suppl 2]29:53 A

    Google Scholar 

  • Goldstein D, Drash A, Gibbs J, Blizzard RM (1970) Diabetes mellitus. The incidence of circulating antibodies against thyroid, gastric and adrenal tissue. J Pediatr 77: 304–306

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb MS, Root HF (1968) Diabetes mellitus in twins. Diabetes 17: 693–704

    PubMed  CAS  Google Scholar 

  • Grodsky GM, Feldman R, Toreson WE, Lee JC (1966) Diabetes mellitus in rabbits immunized with insulin. Diabetes 15: 579–585

    PubMed  CAS  Google Scholar 

  • Gunderson E (1927) Is diabetes of infectious origin? J Infect Dis 41: 197–202

    Article  Google Scholar 

  • Handwerger BS, Fernandes G, Brown DM (1980) Immune and autoimmune aspects of diabetes mellitus. Human Pathology 11: 338–352

    Article  PubMed  CAS  Google Scholar 

  • Hayashi K, Boucher DW, Notkins AL (1974) Virus-induced diabetes mellitus. II. Relationships between beta cell damage and hyperglycemia in mice infected with encephalomyocarditis virus. Am J Pathol 75: 91–102

    Google Scholar 

  • Huang SW, McLaren NK (1976) Insulin-dependent diabetes: a disease of auto-aggression. Science 192: 64–66

    Article  PubMed  CAS  Google Scholar 

  • Irvine WJ (1977) Classification of idiopathic diabetes. Lancet 1: 638–642

    Article  PubMed  CAS  Google Scholar 

  • Irvine WJ (1980) Polyglandular autoimmune diseases. In: Gumming IA, Funder JW, Mendelsohn FAO, Endocrinology 1980. Austral Acad Sci Canberra, pp 100–105

    Google Scholar 

  • Irvine WJ, Barnes EW (1972) Adrenocortical insufficiency. Clin Endocrinol Metab 1: 549–594

    Article  Google Scholar 

  • Irvine WJ, Barnes EW (1974) Addison’s disease and associated conditions with particular reference to premature ovarian failure, diabetes mellitus and hypoparathyroidism. In: Gell PH, Coombs RR A, Lachman PJ (eds) Clinical aspects of immunology,3rd ed. Blackwell Scientific, Oxford, pp 1301 — 1354

    Google Scholar 

  • Irvine WJ, Gray RS, McCallum CJ (1976) Pancreatic islet cell antibody is a marker for asymptomatic and latent diabetes and prediabetes. Lancet 2: 1097–1102

    Article  PubMed  CAS  Google Scholar 

  • Irvine WJ, McCallum CJ, Gray RS, Duncan LJP, Farquhar JW, Vaughan H, Morris PJ (1977 a) Pancreatic islet cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune diseases and HLA type. Diabetes 26: 138–147

    Article  CAS  Google Scholar 

  • Irvine WJ, AI Khateeb SF, Di Mario U, Feek CM, Gray RS, Edmond B, Duncan LJP (1977 b) Soluble immune complexes in the sera of newly diagnosed insulin-dependent diabetics and in treated diabetics. Clin Exp Immunol 30: 16–21

    PubMed  CAS  Google Scholar 

  • Irvine WJ, DiMario U, Feek CM, Gray RS, Ting A, Morris PJ, Duncan LJP (1978 a) Autoimmunity and HLA antigens in type I diabetes. J Clin Lab Immunol 1: 111–114

    Google Scholar 

  • Irvine WJ, DiMario U, Feek CM, Ting A, Morris PJ, Gray RS, Duncan LJP (1978 b) Insulin antibodies in relation to islet cell antibodies and HLA antigens in type I diabetes. J Clin Lab Immunol 1: 107–110

    Google Scholar 

  • Jansen FK, Muntefering H, Schmidt WAK (1978) Virus induced diabetes and the immune system. I. Suggestion that the appearance of diabetes depends on immune reactions. Diabetologia 13: 545–549

    Article  Google Scholar 

  • Jervell J, Solheim B (1979) HLA antigens in longstanding insulin dependent diabetics with terminal nephropathy and retinopathy with and without loss of vision. Diabetologia 17: 391

    Article  PubMed  CAS  Google Scholar 

  • Kawazu S, Kanazawa Y, Kajinuma H, Miki E, Kuzuya T, Kosaka K (1975) Demonstration of anti-“a-component” antibody: a possible means to differentiate patients with auto-antibodies to endogenous insulin from insulin-treated patients. Diabetologia 11: 169–173

    Article  PubMed  CAS  Google Scholar 

  • Kowalczyk D, Zembala M (1978) Migration inhibition of T lymphocytes from human peripheral blood by specific antigen and lymphokines. Clin Exp Immunol 32: 333–338

    PubMed  CAS  Google Scholar 

  • Kozak GP (1971) Diabetes and other endocrinological disorders. In: Marble A, White P, Bradley RF, Krall LP (eds) Joslin’s diabetes mellitus, 11th ed. Lea & Febiger, Philadelphia, pp 666–694

    Google Scholar 

  • Kremer HU (1947) Juvenile diabetes as a sequel to mumps. Am J Med 3: 257–258

    Article  PubMed  CAS  Google Scholar 

  • Lacy PE, Davie JM, Finke EH (1981) Transplantation of insulin producing tissue. Am J med 70: 589–594

    Article  PubMed  CAS  Google Scholar 

  • Larsson O (1967) Studies of small vessels in patients with diabetes. Acta Med Scand [Suppl] 480: 1–66

    CAS  Google Scholar 

  • LeCompte PM, Steinke J, Soeldner JS, Renold AE (1966) Changes in the islets of Langerhans in cows injected with heterologous and homologous insulin. Diabetes 15: 586–596

    PubMed  CAS  Google Scholar 

  • Lendrum R, Walker G, Gamble DR (1975) Islet cell antibodies in juvenile diabetes mellitus of recent origin. Lancet 1: 880–883

    Article  PubMed  CAS  Google Scholar 

  • Lendrum R, Walker G, Cudworth AG, Woodrow JC, Gamble DR (1976 a) HLA-linked genes and islet cell antibodies in diabetes mellitus. Br Med J 1: 1565–1567

    Google Scholar 

  • Lendrum R, Walker G, Cudworth AG, Theophanides C, Pyke DA, Bloom A, Gamble DR (1976 b) Islet cell antibodies in diabetes mellitus. Lancet 2: 1273–1276

    Google Scholar 

  • Lernmark A, Freedman ZR, Hofmann C, Rubinstein AH, Steiner DF, Jackson RL, Winter RJ, Traisman HS (1978) Islet-cell-surface antibodies in juvenile diabetes mellitus. N Engl J Med 299: 375–380

    Article  PubMed  CAS  Google Scholar 

  • Like AA, Rossini AA, Guberski DL, Appel MC, Williams RM (1979) Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science 206: 1421–1423

    Article  PubMed  CAS  Google Scholar 

  • Lipsick J, Beattie G, Osier AG, Kaplan NO (1979) Passive transfer of lymphocytes from diabetic man to athymic mouse. Lancet 1: 1290–1291

    Article  PubMed  CAS  Google Scholar 

  • Ludwig H, Schernthaner G, Kraft D, Scheiner O, Mayr WR (1980) Antibody-dependent killer cell function in insulin-dependent diabetes mellitus. J Endocrinol Invest 3: 39–44

    PubMed  CAS  Google Scholar 

  • MacCuish AC, Irvine WJ (1975) Autoimmunological aspects of diabetes mellitus. Clin Endocrinol Metab 4: 435–471

    Article  Google Scholar 

  • MacCuish AC, Jordan J, Campbell CJ, Duncan LJP, Irvine WJ (1974 a) Cell-mediated immunity to human pancreas in diabetes mellitus. Diabetes 23: 693–697

    Google Scholar 

  • MacCuish AC, Barnes EW, Irvine WJ, Duncan LJP (1974 b) Antibodies to pancreatic islet cells in insulin-dependent diabetes with coexistent autoimmune disease. Lancet 2: 1529–1531

    Google Scholar 

  • MacLaren, NK, Huang SW, Fogh J (1975) Antibody to cultured human insulinoma cells in insulin-dependent diabetes. Lancet 1: 997–1000

    Article  PubMed  CAS  Google Scholar 

  • Matas AJ, Sutherland DER, Najarian JS (1976) Current status of islet and pancreatic transplantation in diabetes. Diabetes 25: 785–795

    PubMed  CAS  Google Scholar 

  • Melin K, Ursing B (1958) Diabetes mellitus som komplikation till parotitis epidemica. Nord Med 60: 1715–1717

    PubMed  CAS  Google Scholar 

  • Moulias R, Goust JM (1974) Cell-mediated immune responses against insulin in low insulin output diabetes and in diabetes with lipo-atrophy. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 121–123

    Google Scholar 

  • Moulias R, Goust JM, Bernard S, Croisier B, Attali A, Berthaux P (1974) Humoral and cellular thyroid auto-immunity and diabetes mellitus. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 140–148

    Google Scholar 

  • Muntefering H (1974) Experimental virus-induced diabetes mellitus accompanied by insulitis. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 234–241

    Google Scholar 

  • Nakao Y, Fukunishi T, Koide M, Akasawa K, Ikeda M, Mikio Y, Imura H (1977) HLA antigens in Japanese patients with diabetes mellitus. Diabetes 26: 736–739

    Article  PubMed  CAS  Google Scholar 

  • Nakhooda AF, Like AA, Chappel CI, Murray FR, Marliss EB (1977) The spontaneously diabetic Wistar rat; metabolic and morphologic studies. Diabetes 26: 100–112

    Article  PubMed  CAS  Google Scholar 

  • Nelson PG, Pyke DA, Gamble DR (1975) Viruses and the aetiology of diabetes: a study in identical twins. Br Med J 4: 249–251

    Article  PubMed  CAS  Google Scholar 

  • Nerup J (1974) The clinical and immunological association of diabetes mellitus and Addison’s disease. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 149–152

    Google Scholar 

  • Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE (1971) Anti-pancreatic cellular hypersensitivity in diabetes mellitus. Diabetes 20: 424–427

    PubMed  CAS  Google Scholar 

  • Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE, Vilien M, Westrup M (1973 a) Antipancreatic cellular hypersensitivity in diabetes mellitus: experimental induction of anti-pancreatic cellular hypersensitivity and associated morphological B-cell changes in the rat. Acta Allergol 28: 231–249

    Google Scholar 

  • Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE ( 1973 b) Anti-pancreatic cellular hypersensitivity in diabetes mellitus. Antigen activity of fetal calf pancreas and correlation with clinical type of diabetes. Acta Allergol 28: 223–230

    CAS  Google Scholar 

  • Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE (1974) Cellular hypersensitivity to islet cell antigen(s) different from insulin in diabetes mellitus. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 107–111

    Google Scholar 

  • Nerup J, Andersen OO, Christy M, Platz P, Thomsen M, Svejgaard A, Bottazzo GH, Pouplard A, Doniach D (1975) HLA factor, autoimmunity, virus and juvenile diabetes mellitus. Diabetologia 11: 365–366

    Google Scholar 

  • Nissley SP, Drash AL, Blizzard RM, Sperling M, Childs, B (1973) Comparison of juvenile diabetics with positive and negative organ-specific antibody titers. Evidence for genetic heterogeneity. Diabetes 22: 63–65

    PubMed  CAS  Google Scholar 

  • Notkins AL (1977) Virus-induced diabetes mellitus: a brief review. Arch Virol 54: 1–17

    Article  PubMed  CAS  Google Scholar 

  • Notkins AL (1979) The causes of diabetes. Sci Am 241: 62–73

    Article  PubMed  CAS  Google Scholar 

  • Ogle JW (1866) On disease of the brain as a result of diabetes mellitus. St. George’s Hosp Rep 1: 157–188

    Google Scholar 

  • Ohneda A, Matsuda K, Sato M, Yamagata S, Sato T (1974) Hypoglycaemia due to apparent autoantibodies to insulin: characterization of insulin-binding protein. Diabetes 23: 41–50

    Google Scholar 

  • Onodera T, Jenseon AB, Yoon JW, Notkins AL (1978) Virus–induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice. Science 201: 529–531

    Article  PubMed  CAS  Google Scholar 

  • Osserman KG (1969) Muscles (myasthenia gravis). In: Miescher PA, Muller-Eberhard HJ (eds) Textbook of immunopathology, vol 2. Grune & Stratton, New York, pp 607–623

    Google Scholar 

  • Paik SG, Fleischer N, Shin SI (1980) Induction of diabetes by streptozotocin is mediated by T-cell functions (Abstract 205). Diabetes [Suppl 2]29: 52A

    Google Scholar 

  • Parkinson J (1910) A case of pernicious anaemia terminating in acute diabetes. Lancet 2: 543–546

    Article  Google Scholar 

  • Pozzilli P, Sensi M, Gorsuch A, Bottazzo GH, Cudworth AG (1979) Evidence for raised K cell levels in type I diabetes. Lancet 2: 173–175

    Article  PubMed  CAS  Google Scholar 

  • Pozzilli P, Andreani D, Sensi M, Wolf E, Taylor M, Bottazzo GF, Cudworth AG (1980) K cells and antibody dependent cytotoxicity in autoimmune polyendocrine disease. 6th Internat Endocrinol Cong, Melbourne, Australia, 10–14 February 1980, Abstract 639, p 529 (to be published)

    Google Scholar 

  • Pyke DA (1979) Diabetes: the genetic connections. Diabetologia 17: 333–344

    Article  PubMed  CAS  Google Scholar 

  • Pyke DA, Nelson PG (1976) Diabetes mellitus in identical twins. In: Creutzfeldt W, Kobberling J, Neel JV (eds) The genetics of diabetes mellitus. Springer, Berlin Heidelberg New York, pp 194–202

    Google Scholar 

  • Rayfield EJ, Seto Y (1978) Viruses and the pathogenesis of diabetes mellitus. Diabetes 27: 1126–1140

    PubMed  CAS  Google Scholar 

  • Richens ER, Ancil RJ, Hartog M (1976) Autoimmunity and viral infection in diabetes mellitus. Clin Exp Immunol 23: 40–46

    PubMed  CAS  Google Scholar 

  • Riley W, MacLaren N, Rand K, Bejar R (1980) Inherited autoimmunity versus Coxsackie B4 in insulin dependent diabetes (Abstract 211). Diabetes [Suppl 2]29: 53A

    Google Scholar 

  • Rodney G, White N, Frazer TE, Duquesnay RJ, Santiago JV (1979) HLA DR specificities among black Americans with juvenile-onset diabetes. N Engl J Med 301: 810–812

    Article  Google Scholar 

  • Rolles CJ, Rayner PHW, MacKintosh P (1975) Aetiology of juvenile diabetes. Lancet 2: 230

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal MB, Goldfine ID, Siperstein MD (1976) Genetic origin of diabetes: re-evaluation of twin data. Lancet 2: 250–251

    Article  PubMed  CAS  Google Scholar 

  • Ross ME, Onodera T, Brown KS, Notkins AL (1976) Virus-induced diabetes mellitus. IV. Genetic and environmental factors influencing the development of diabetes after infection with the M variant of encephalomyocarditis virus. Diabetes 25: 190–197

    Google Scholar 

  • Rubinstein P, Suciu-Foca N, Nicholson JF (1977) Genetics of juvenile diabetes mellitus. A recessive gene clearly linked to HLA D and with 50% penetrance. N Engl J Med 297: 1036–1040

    Article  PubMed  CAS  Google Scholar 

  • Sasazuki T, Kohno Y, Iwamoto I, Kosaka K, Okimoto K, Maruyama H, Ishiba S, Konishi J, Takeda Y, Naito S (1978) HLA and Graves1 disease or diabetes mellitus in Japan. N Engl J Med 298: 630–631

    PubMed  CAS  Google Scholar 

  • Schernthaner G, Ludwig H, Mayr WR (1979) Immunoglobulin G–insulin antibodies and immune-region associated alloantigens in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 48: 403–407

    Article  PubMed  CAS  Google Scholar 

  • Solomon N, Carpenter CJC, Bennett IL, Harvey AM (1965) Schmidt’s syndrome (thyroid and adrenal insufficiency) and coexistent diabetes mellitus. Diabetes 14: 300–304

    Google Scholar 

  • Solow H, Hidalgo R, Blajchman M, Singal DP (1977) HLA, B, C and B lymphocyte alloantigens in insulin-dependent diabetes. Transplant Proc 9: 1859–1861

    PubMed  CAS  Google Scholar 

  • Tan JS, Anderson JL, Watanakunakorn C, Phair JP (1975) Neutrophil dysfunction in diabetes mellitus. Diabetes 14: 300–304

    Google Scholar 

  • Tattersall RB, Pyke DA (1972) Diabetes in identical twins. Lancet 2: 1120–1125

    Article  PubMed  CAS  Google Scholar 

  • Taylor KW (1974) The diabetogenic effect of Coxsackie B viruses. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp 242–244

    Google Scholar 

  • Then Bergh H (1939) Zur Frage der psychischen und neurologischen Erscheinungen bei Diabeteskranken und deren Verwandten. Z Gesamte Neurol Psychiatr 165: 278–283

    Article  Google Scholar 

  • Thurneyssen O, Jansen FK, Vialettes B, Vague Ph, Selam JL, Mirouze J (1979) Passive transfer of lymphocytes from diabetic man to athymic mouse. Lancet 1: 1291–1292

    PubMed  CAS  Google Scholar 

  • Totterman TH, Andersson LC, Hayry P (1979) Evidence for thyroid antigen-reactive T lymphocytes infiltrating the thyroid gland in Graves’ disease. Clin Endocrinol (Oxf) 11: 59–68

    Article  CAS  Google Scholar 

  • Ungar B, Whittingham S, Francis CM (1967) Pernicious anaemia; incidence and significance of circulating antibodies to intrinsic factor and to parietal cells. Aust Ann Med 16: 226–229

    PubMed  CAS  Google Scholar 

  • Volpe R (1978) The pathogenesis of Graves’ disease: an overview. Clin Endocrinol Metab 7: 3–29

    Article  PubMed  CAS  Google Scholar 

  • Volpe R, Edmonds M, Lamki L, Clarke PV, Row VV (1972) The pathogenesis of Graves’ disease: a disorder of delayed hypersensitivity? Mayo Clin Proc 47: 824–834

    PubMed  CAS  Google Scholar 

  • Von Meyenburg H (1940) Über “insulitis” bei Diabetes. Schweiz Med Wochenschr 70: 554–557

    Google Scholar 

  • Wakisaka A, Aizawa M, Matsurra N, Nakazawa S, Nakayama E, Ilakura K, Okuno A, Wagatsuma Y (1976) HLA and juvenile diabetes mellitus in the Japanese. Lancet 2: 970

    Article  PubMed  CAS  Google Scholar 

  • Webb SR, Loria RM, Madge GE, Kilbrick S (1976) Susceptibility of mice to Group B Coxsackie virus is influenced by the diabetic gene. J Exp Med 143: 1239–1248

    Article  PubMed  CAS  Google Scholar 

  • Wellmann KF, Amsterdam D, Brancato P, Volk BW (1972) Fine structure of the pancreatic islets of mice infected with the M variant of the encephalomyocarditis virus. Diabetologia 8: 349–357

    Article  Google Scholar 

  • Werner AU, Larsen HW (1969) Immunohistological studies on human diabetic and non-diabetic eyes. I. Fluorescent labelling of insulin and insulin antibodies. Acta Ophthalmol 47: 937–955

    Google Scholar 

  • Westberg NG, Michael AF (1972) Immunohistopathology of diabetic glomerulosclerosis. Diabetes 21: 163–174

    PubMed  CAS  Google Scholar 

  • Yalow RS, Berson SA (1957) Apparent inhibition of liver insulinase activity by serum and serum fractions containing insulin binding antibody. J Clin Invest 36: 648–655

    Article  PubMed  CAS  Google Scholar 

  • Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39: 1157–1175

    Article  PubMed  CAS  Google Scholar 

  • Yalow RS, Berson SA (1961) Immunological specificity of human insulin: application to immunoassay of insulin. J Clin Invest 40: 2190–2198

    Article  PubMed  CAS  Google Scholar 

  • Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300: 1173–1179

    Article  PubMed  CAS  Google Scholar 

  • Zeidler A, Loon J, Fraser SD, Kunar D, Perry R, Terasaki P (1980) HLA DRw antigens in Mexican-American and black American diabetic patients. Diabetes 29: 247–256

    Article  PubMed  CAS  Google Scholar 

  • Zonana J, Rimoin DL (1976) Inheritance of diabetes mellitus. N Engl J Med 295: 603–605

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, University of Toronto, M4Y 1J3, Toronto, Ontario, Canada

    Robert Volpé M.D., F.R.C.P.(C), F.A.C.P. (Professor, Physician-in-Chief)

  2. The Wellesley Hospital, M4Y 1J3, Toronto, Ontario, Canada

    Robert Volpé M.D., F.R.C.P.(C), F.A.C.P. (Professor, Physician-in-Chief)

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  1. Robert Volpé M.D., F.R.C.P.(C), F.A.C.P.
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© 1981 Springer-Verlag Berlin, Heidelberg

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Volpé, R. (1981). Auto-immunity in Diabetes Mellitus. In: Auto-immunity in the Endocrine System. Monographs on Endocrinology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81624-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-81624-6_3

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