Advertisement

Hirsutism pp 15-15 | Cite as

Hepatic Metabolism

  • Pierre Mauvais-Jarvis
  • Frédérique Kuttenn
  • Irène Mowszowicz
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 19)

Abstract

Like all steroid hormones, androgens are extensively metabolized in the liver. The metabolism results in inactive steroids which are thereafter eliminated mainly in the urine. Three types of reaction are essential: oxidation of the 17β-hydroxy group, reduction of the double bond and of the 3-keto group, and conjugation with glucuronic or sulphuric acid. Thus the main urinary metabolites of androgens are 17-ketosteroids with a reduced A ring. The existence of 5α-, 3α- and 3β-reductases has been demonstrated in the liver.

Keywords

Public Health Biological Action Double Bond Small Proportion Sulphuric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Pierre Mauvais-Jarvis
    • 1
    • 2
  • Frédérique Kuttenn
    • 1
    • 2
  • Irène Mowszowicz
    • 1
    • 2
  1. 1.Department of Reproductive EndocrinologyHôpital NeckerParis Cedex 15France
  2. 2.Department of BiochemistryFaculty of Medicine Pitié-SalpétrièreParis Cedex 13France

Personalised recommendations