Abstract
The bleomycins, discovered in 1966 by Umezawa and colleagues [12], have been the focus of intense interest for a number of years. Unique molecular pharmacologic, clinical pharmacologic, and toxicologic characteristics, and substantial clinical activities have resulted in significant analog development efforts. At present more than 300 analogs of bleomycin have been reported, and these analogs can be divided into three generations. First generation analogs can be thought of as the initial 13 bleomycins isolated. Second generation analogs are those that differ from the initial bleomycins only by changes in the terminal amine structure, or by very minor modifications in the bleomycinic acid portion of the molecule. Third generation analogs can be thought of as those differing significantly from the bleomycins in the bleomycinic acid portion of the molecule. The tallysomycins are third generation bleomycin analogs.
The authors thank Ms. Julie Durantini for excellent typographical assistance, and Dr. Harris Busch for his continuing guidance and support
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References
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© 1981 Springer-Verlag Berlin Heidelberg
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Crooke, S.T., Strong, J.E., Bradner, W.T., Schurig, J., Schlein, A., Prestayko, A.W. (1981). Tallysomycin, A Third Generation Bleomycin Analog. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_7
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DOI: https://doi.org/10.1007/978-3-642-81565-2_7
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