Abstract
Chemotherapy has had only a limited role in the treatment of recurrent squamous cell cancer of the head and neck. Methotrexate (MTX), the most extensively studied drug, produces 30%–50% response rates. Most of these responses, however, are of short duration [1]. Although response rates with high-dose MTX with leucovorin rescue (LR) have not been shown to be superior to those with conventional doses of MTX [5, 12], the relative lack of hematologic toxicity with the high-dose regimen [13, 14] may be advantageous when MTX is combined with other chemotherapeutic agents.
This study was supported by National Cancer Institute, National Institute of Health, Grant CA 05838 and a gift from the Bristol-Myers Company. The author thanks Michael Friedman, MD, for his contribution of clinical material
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© 1981 Springer-Verlag Berlin Heidelberg
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Jacobs, C. (1981). High-Dose Methotrexate and Cis-Platinum in the Treatment of Recurrent Head and Neck Cancer. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_26
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DOI: https://doi.org/10.1007/978-3-642-81565-2_26
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