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Combination Chemotherapy of Head and Neck Cancer in the United States

  • R. E. Wittes
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 76)

Abstract

In 1973 Bertino and co-workers [3] reviewed the chemotherapy of head and neck cancer. They concluded that “several agents are effective in the treatment of epidermoid cancers of the head and neck. The time is ripe for the development of effective drug combinations and programs utilizing chemotherapy, radiation therapy, and surgery in the treatment of these difficult neoplasms.” During the six years that have elapsed since those words were written, oncologists have been working busily along these very lines. In doing so, they have been spurred on by several factors: a resurgence of interest in methotrexate, particularly in high dose with leucovorin rescue; the identification of cis-diammine-dichloroplatinum (II) as an agent with significant activity in these tumors; and, perhaps most important, the climate of general optimism surrounding the combined-modality approach to human solid tumors. In this review we shall examine the general directions of systemic drug therapy for epidermoid carcinoma of the head and neck (ECHN) in the United States over the past few years. We shall not deal with intra-arterial chemotherapy or with the combination of single drugs and radiotherapy, both of which have been reviewed in detail elsewhere [3, 9, 20, 27].

Keywords

Clin Oncol Neck Cancer Combination Chemotherapy Epidermoid Carcinoma Advanced Head 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • R. E. Wittes
    • 1
  1. 1.Solid Tumor Service, Department of MedicineMemorial-Sloan-Kettering Cancer CenterNew YorkUSA

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