The FAM Regimen for Gastric Cancer: A Progress Report
The FAM regimen for upper gastrointestinal cancer was developed during 1974. It incorporated three anticancer drugs which had demonstrated independent activity against gastric cancer: 5-fluorouracil, adriamycin , and mitomycin-C . In an attempt to insure adequate patient tolerance and allow for chronic administration, an intermittent schedule was designed (Table 1). In particular, mitomycin-C was to be administered only once every 2 months because of its then appreciated delayed and cumulative bone marrow toxicity. We have recently reported the criteria for entry into this study, including the strict requirement for followable disease criteria for patient response, as well as the initial response rates and survival curves . This progress report describes the updated results in the treatment of 62 patients with advanced and measurable gastric cancer.
KeywordsToxicity Adriamycin Chloroethylnitrosourea
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