A Review of Clinical Studies on Bestatin, 1976–1978

Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 76)


As Professor Umezawa et al. found bestatin inhibits aminopeptidase B and leucine aminopeptidase, binds to the surface of animal cells including macrophages and lymphocytes, enhances delayed-type hypersensitivity, and exhibits antitumor effect on slowly growing experimental solid tumors. Moreover, bestatin treatment enhances the therapeutic effect of chemotherapeutic agents such as bleomycin and adriamycin on experimental animal tumors. Bestatin has extremely low toxicity by both parenteral and oral administration. Bestatin is a small molecular compound and does not have any antigenicity.


Penile Cancer Leucine Aminopeptidase Anticancer Chemotherapy Cancer Patient Treat Optimal Dose Schedule 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. Oka
    • 1
  1. 1.Institute of Microbial ChemistryShinagawa-ku, Tokyo 141Japan

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