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A Review of Clinical Studies on Bestatin, 1976–1978

Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 76)

Abstract

As Professor Umezawa et al. found bestatin inhibits aminopeptidase B and leucine aminopeptidase, binds to the surface of animal cells including macrophages and lymphocytes, enhances delayed-type hypersensitivity, and exhibits antitumor effect on slowly growing experimental solid tumors. Moreover, bestatin treatment enhances the therapeutic effect of chemotherapeutic agents such as bleomycin and adriamycin on experimental animal tumors. Bestatin has extremely low toxicity by both parenteral and oral administration. Bestatin is a small molecular compound and does not have any antigenicity.

Keywords

Penile Cancer Leucine Aminopeptidase Anticancer Chemotherapy Cancer Patient Treat Optimal Dose Schedule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Aoyagi T, Suda H, Nagai M, Ogawa K, Suzuki J, Takeuchi T, Umezawa H (1976) Aminopeptidase activities on the surface of mammalian cells. Biochim Biophys Acta 452:131–143PubMedCrossRefGoogle Scholar
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    Kondo T, Watanabe N, Tachibana T (1978) Rapid and simple assay in microtest plate for enumeration of human T and B lymphocyte populations (in Japanese). Igaku No Ayumi 107:312–314Google Scholar
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    Tachibana T, Yoshida A (1974) Determination of human T and B lymphocyte populations in microtest plate (an improved method). In: Japanese Society for Immunology (eds) Experimental methods in immunology A (in Japanese), pp 907–914Google Scholar
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    Umezawa H, Aoyagi T, Suda H, Hamada M, Takeuchi T (1976) Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot (Tokyo) 29:97–99CrossRefGoogle Scholar
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    Umezawa H, Ishizuka M, Aoyagi T, Takeuchi I (1976) Enhancement of delayed-type hypersensivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase. J Antibiot (Tokyo) 29:857–859CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. Oka
    • 1
  1. 1.Institute of Microbial ChemistryShinagawa-ku, Tokyo 141Japan

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