A Review of Clinical Studies on Bestatin, 1976–1978
As Professor Umezawa et al. found bestatin inhibits aminopeptidase B and leucine aminopeptidase, binds to the surface of animal cells including macrophages and lymphocytes, enhances delayed-type hypersensitivity, and exhibits antitumor effect on slowly growing experimental solid tumors. Moreover, bestatin treatment enhances the therapeutic effect of chemotherapeutic agents such as bleomycin and adriamycin on experimental animal tumors. Bestatin has extremely low toxicity by both parenteral and oral administration. Bestatin is a small molecular compound and does not have any antigenicity.
KeywordsToxicity Lymphoma Cobalt Adenocarcinoma Sarcoma
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