Abstract
The author initiated the screening study of enzyme inhibitors produced by microorganisms in 1965, and found about 50 new microbial products. These small molecular enzyme inhibitors have various bioactivities, but no significant antimicrobial activity. The finding of these inhibitors indicates that microorganisms in nature have acquired the ability to produce various compounds that have no obvious function in the growth of microbial cells and that have widely varied chemical structures [12, 14]. Therefore, if an exact screening method can be established, it is reasonable to search for small molecular microbial products which can modulate immune responses.
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© 1981 Springer-Verlag Berlin Heidelberg
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Umezawa, H. (1981). Fundamental Studies on Bestatin: A Small Molecular Microbial Product Enhancing Immune Responses. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_17
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DOI: https://doi.org/10.1007/978-3-642-81565-2_17
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