Skip to main content
SpringerLink
Log in

New Natural Products Under Development at the National Cancer Institute

  • Conference paper
New Drugs in Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 76))

Summary

Twenty-six new agents of natural products origin which are under preclinical development as potential antitumor agents at the National Cancer Institute are discussed with reference to their sources, structures, antitumor activity, current status, and future potential as clinically effective drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berger J, Jampolsky IM, Goldberg MW (1949) Borrelidin, a new antibiotic with anti-borrelia activity and penicillin enhancement properties. Arch Biochem Biophys 22:476–478

    CAS  Google Scholar 

  2. Brundret KM, Dalziel W, Hesp B, Jarvis JAJ, Neidle S (1972) X-ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system. J Chem Soc Chem Commun 1972:1027-1028

    Article  Google Scholar 

  3. Bucknall RA, Moores H, Simms R, Hesp B (1973) Antiviral effects of aphidicolin, a new antibiotic produced by cephalosporium aphidicola. Antimicrob Agents Chemother 4:294–298

    Article  PubMed  CAS  Google Scholar 

  4. Cephalotaxus Research Coordinating Group (1976) Cephalotaxine esters in the treatment of acute leukemia: A preliminary clinical assessment. Chin Med J [Engl] 2:263–272

    Google Scholar 

  5. Dalziel W, Hesp B, Stevenson KM, Jarvis JAJ (1973) The structure and absolute configuration of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system. J Cehm Soc [Perkin I] pp 2841–2851

    Google Scholar 

  6. Douros JD (1978) National Cancer Institute’s fermentation development program. In: Carter SK, Umezawa H, Douros J, Sakurai Y (eds) Recent results in cancer research, vol 63. Springer, Berlin Heidelberg New York, pp 34–48

    Google Scholar 

  7. Douros J, Suffness M (1978) New natural products of interest under development at the National Cancer Institute. Cancer Chemother Pharmacol 1:91–100

    Article  PubMed  CAS  Google Scholar 

  8. Formica JV, Shatkin AJ, Katz E (1968) Actinomycin analogues containing pipecolic acid: relationship of structure to biological activity. J Bacteriol 95:2139–2150

    PubMed  CAS  Google Scholar 

  9. Furukawa M, Inoue A, Asand K, Kawamata J (1968) Chemical studies on actinomycin S. II. chemical structures of actinomycin S2 and S3. J Antibiot (Tokyo) 21:568–570

    Article  CAS  Google Scholar 

  10. Geran RL, Greenberg NH, MacDonald MM, Schumacher AM, Abbott BJ (1972) Protocols for screening chemical agents and natural products against animal tumors and other biological systems (3rd ed). Cancer Chemother Rep Part 33:1–103

    Google Scholar 

  11. Hanka LJ, Dietz A, Gerpheide SA, Kuentzel SL, Martin DG (1978) CC-1065 (NSC-298223) a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing organism. J Antibiot (Tokyo) 31:1211-1217

    Article  CAS  Google Scholar 

  12. Katz E (1960) Biogenesis of the actinomycins. Ann NY Acad Sci 89:304-322

    Article  PubMed  CAS  Google Scholar 

  13. Kawaguchi H, Tsukiura H, Tomita K, Konishi M, Saito K, Kobaru S, Numata K, Fujisawa K, Miyaki T, Hatori M, Koshiyama H (1977) Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties. J Antibiot (Tokyo) 30:779-788

    Article  CAS  Google Scholar 

  14. KeUer-Schierlein W (1966) Die Konstitution des Borrelidins. Experientia 22:355–363

    Article  Google Scholar 

  15. Konishi M, Saito K, Numata K, Tsuno T, Asama K, Tsukiura H, Naito T, Kawaguchi H (1977) Tallysomycin, a new antitumor antibiotic complex related to bleomycin. II. Structure determination of tallysomycins A and B. J Antibiot (Tokyo) 30:789–805

    Article  CAS  Google Scholar 

  16. Kupchan SM, Court WA, Dailey RG, jr, Gilmore CJ, Bryan RF (1972) Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc 94:7194–7195

    Article  PubMed  CAS  Google Scholar 

  17. Kupchan SM, Jarvis BB, Dailey RG, jr, Bright W, Bryan RF, Shizuri Y (1976) Baccharin, a novel potent antileukemic trichothecenetriepoxide from Baccharis megapotamica. J Am Chem Soc 98:7092–7093

    Article  PubMed  CAS  Google Scholar 

  18. Kupchan SM, Ashmore JW, Sneden AT (1977) Eriofertopin and2–0-acetyleriofertopin, new tumor inhibitory germacradienolides from Eriophyllum confertiflorum. Phytochemistry 16:1834–1835

    Article  CAS  Google Scholar 

  19. Kupchan SM, Lavoie EJ, Branfman AR, Fei BY, Bright WM, Bryan RF (1977) Phyllanthocin, a novel bisabolane aglycone from the antileukemic glycoside, phyllanthoside. J Am Chem Soc 99:3199–3201

    Article  PubMed  CAS  Google Scholar 

  20. Kupchan SM, Streelman DR, Jarvis BB, Dailey RG, jr, Sneden AT (1977) Isolation of potent new antileukemic trichothecenes from baccharis megapotamica. J Org Chem 42:4221–4225

    Article  PubMed  CAS  Google Scholar 

  21. Martin DG, Mizsak SA, Biles C, Stewart JC, Baczynskyj L, Meulman PA (1975) Structure of quinomycin antibiotics. J Antibiot (Tokyo) 28:332-336

    Article  CAS  Google Scholar 

  22. Matsuda A, Yoshioka O, Yamashita T, Ebihara K, Umezawa H, Miura T, Katayama K, Yokoyama M, Nagai S (1978) Fundamental and clinical studies on new bleomycin analogs. In: Carter SK, Umezawa H, Douros J, Sakura Y (eds) Recent results in cancer, vol 63. Springer, Berlin Heidelberg New York, pp 191–210

    Google Scholar 

  23. Oki T, Matsuzawa Y, Yoshimoto A, Numata K, Kitamura I, Hori S, Takamatsu A, Umezawa H, Ishizuka M, Naganawa H, Suda H, Hamada M, Takeuchi T (1975) New antitumor antibiotics, aclacinomycins A and B. J Antibiot (Tokyo) 28:830–834

    Article  CAS  Google Scholar 

  24. Powell RG, Weisleder D, Smith CR, Jr, Rohwedder WK (1970) Structures of harringtonine, isoharringtonine, and homoharringtonine. Tetrahedron Lett 1970:815–818

    Article  Google Scholar 

  25. Sakano T, Okazaki N, Ise T, Kitaoka K, Kimura K (1978) Phase 1 study of aclacinomycin A. Jpn J Clin Oncol 8:49–53

    Google Scholar 

  26. Suffness M, Douros J (1979) Drugs of plant origin. In: Devita VT, Jr, Busch H (eds) Methods in cancer research, vol XVI A. Academic Press, New York, pp 73–126

    Google Scholar 

  27. Wani MC, Taylor HL, Wall ME, Coggon P, MCPHAII AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from taxus brevifolia. J Am Chem Soc 93:2325–2327

    Article  PubMed  CAS  Google Scholar 

  28. Wiley PF, Johnson JL, Houser DJ (1977) Nogalomycin analogs having improved antitumor activity. J Antibiot (Tokyo) 30:628–629

    Article  CAS  Google Scholar 

  29. Yamaguchi T, Furumai T, Sato M, Okuda T, Ishida N (1970) Studies on a new antitumor antibiotic, largomycin. I. Taxonomy of the largomycin-producing strain and production of the antibiotic. J Antibiot (Tokyo) 23:369–372

    Article  CAS  Google Scholar 

  30. Yamaguchi T, Kashida T, Nawa K, Yajima T, Miyagishima T, Ito Y, Okuda T, Ishida N, Kumagi K (1970) Studies on a new antitumor antibiotic, largomycin. II. Isolation, purification and physicochemical properties. J Antibiot (Tokyo) 23:373–381

    Article  CAS  Google Scholar 

  31. Yamaguchi T, Sato M, Omura Y, Arai Y, Enomoto K, Ishida M, Kumogai K (1970) Studies on a new antitumor antibiotic, largomycin. III. Biological properties and antitumor activity of largomycin F-II. J Antibiot (Tokyo) 23:382–387

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, USA, Bethesda, MD

    J. Douros & M. Suffness

Authors
  1. J. Douros
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Suffness
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Northern California Cancer Program, 1801 Page Mill Road, Suite 200, Building B, Palo Alto, CA, 94304, USA

    Stephen K. Carter

  2. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan

    Yoshi Sakurai

  3. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo 141, Japan

    Hamoa Umezawa

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Douros, J., Suffness, M. (1981). New Natural Products Under Development at the National Cancer Institute. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81565-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81567-6

  • Online ISBN: 978-3-642-81565-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation