Role of the Golgi Complex in Intracellular Transport

  • V. Herzog
Part of the Colloquium der Gesellschaft für Biologische Chemie book series (MOSBACH, volume 31)


In 1898, the Italian histologist Camillo Golgi (1898a,b) described reticular structures in the cytoplasm of nerve cells which he called “apparato reticolare interno”. He used a capricious and little-understood silver staining technique for its visualization. The first direct evidence that this structure is not due to a staining artifact came from electron microscopic observations (Dalton and Felix 1954). With the technical progress in cell-biological areas such as cell fractionation and electron microscope-cytochemistry and -autoradiography, the analysis of structural, kinetic and chemical characteristics of the Golgi complex became possible. Since its discovery, the Golgi complex has been looked upon as functioning in the secretory process. Therefore, knowledge on the structure and function of the Golgi complex accumulated with the increasing interest in the analysis of the secretory process. This was studied primarily in secretory cell types such as the exocrine pancreas. However, all eukaryotic cells release secretory products permanently, intermittently, or at some stage of their development. Because of the great variability in the specific function among cells, numerous variations on the common theme of the secretory process (Palade 1975) and, in particular, on the functions of the Golgi apparatus, were discovered. It became clear that the Golgi apparatus is a station in the secretory pathway where the secretory product is modified while in transit. Because secretory products are segregated from the cytoplasm by a membrane at all stations, it has been assumed that their intracellular transport implies the concomitant transfer of membranes or of membrane constituents.


Golgi Apparatus Rough Endoplasmic Reticulum Golgi Complex Exocrine Pancreas Golgi Cisterna 
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© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • V. Herzog
    • 1
  1. 1.Institut für ZellbiologieUniversität MünchenMünchen 2Germany

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