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Pallido-Luyso-Nigral Atrophy and Amyotrophic Lateral Sclerosis

  • F. Gray
  • C. De Baecque
  • M. Serdaru
  • R. Escourolle
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 7)

Summary

Clinical and neuropathological studies of a case of pallido-luyso-nigral atrophy and amyotrophic lateral sclerosis (ALS) in a young woman with a strong likelyhood of a similar familial past medical history have been presented. Microscopic examination revealed neuronal loss and gliosis of globus pallidus, corpus luysii and substantia nigra. Pallor of the pyramidal tracts and neuronal loss in hypoglossal nuclei and anterior horns with gliosis were present. The rarity of the association of a pallido-luyso-nigral atrophy and an ALS, the occurrence of an ALS at such a young age and the fact that her grandmother died of Parkinson disease at age 30 suggest that this association may represent more than a coincidental occurrence.

Key words

pallido-luyso-nigral atrophy corpus luysii amyotrophic lateral sclerosis 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • F. Gray
    • 1
    • 2
  • C. De Baecque
    • 1
  • M. Serdaru
    • 1
  • R. Escourolle
    • 1
  1. 1.Laboratoire de Neuropathologie Charles FoixHopital de la SalpétrièreParis Cedex 13France
  2. 2.Laboratoire de Neuropathologie Charles FoixHopital de la SalpétrièreParis CedexFrance

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