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Basophilic Inclusions in Skeletal Muscle from two Cases of Hypothyroid Myopathy

  • Conference paper
Experimental and Clinical Neuropathology

Part of the book series: Acta Neuropathologica Supplementum ((NEUROPATHOLOGIC,volume 7))

Summary

We have been able to examine muscular tissue from two females showing hypothyroid myopathy. Under light microscopy, certain fibres contained basophilic inclusions. Histoenzymology showed that these inclusions were found exclusively in certain type 1 fibres. Ultrastructural examination showed that the inclusions were accumulations without a limiting membrane. These accumulations contained straight fibrils which were randomly distributed. Their mean diametre was 70 Å. The neighbouring myofibrils were usually unaltered. We have found similar images described for five cases of hypothyroid myopathies. They are more common in myocardium than in skeletal muscle. These images are similar to those observed in some cases of type IV glycogenosis and Lafora’s disease.

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Authors and Affiliations

  1. Centre de Microscopie Electronique, l’Université de Bordeaux II, France

    Docteur M. Coquet, J. M. Vallat & J. L. Latapie

  2. Centre de Microscopie Electronique, Université de Bordeaux II, 146 Rue Leo Saignat, 33076, Bordeaux, France

    Docteur M. Coquet

Authors
  1. Docteur M. Coquet
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  2. J. M. Vallat
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  3. J. L. Latapie
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Editor information

Editors and Affiliations

  1. Ludwig Boltzmann-Institute of Clinical Neurobiology, Lainz-Hospital, Wolkersbergenstraße 1, 1130, Wien, Austria

    Kurt Jellinger (Director) (Director)

  2. Institut für Neuropathologie, Universität Bonn, 5300, Bonn-Venusberg, Germany

    Filippo Gullotta

  3. Institute of Brain Research, Polish Academy of Sciences, 3, ul. Dworkowa, Warsaw, Poland

    Miroslav Mossakowski (Director) (Director)

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© 1981 Springer-Verlag

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Coquet, M., Vallat, J.M., Latapie, J.L. (1981). Basophilic Inclusions in Skeletal Muscle from two Cases of Hypothyroid Myopathy. In: Jellinger, K., Gullotta, F., Mossakowski, M. (eds) Experimental and Clinical Neuropathology. Acta Neuropathologica Supplementum, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81553-9_92

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  • DOI: https://doi.org/10.1007/978-3-642-81553-9_92

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10449-0

  • Online ISBN: 978-3-642-81553-9

  • eBook Packages: Springer Book Archive

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