Ultrastructural Variability of Demyelinating Lesions in Experimental Allergic Encephalomyelitis and Multiple Sclerosis

  • H. Lassmann
  • K. Kitz
  • H. M. Wisniewski
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 7)


The pathology of chronic relapsing experimental encephalomyelitis (EAE) and multiple sclerosis are similar in several essential aspects. The similarities include the perivenous inflammation, primary segmental demyelination, formation of large, macrosco-pically visible demyelinated plaques, reactive gliosis and variable degree of remyelination (5). Differences, however, were stressed by several authors mainly regarding size of the lesions, growth of actively demyelinating lesions, involvement of inflammatory cells in the demyelinating process with special emphasis on macrophage response, role of local cells in demyelination and removal of debris and vascular (capillary) pathology.

Key words

demyelinating lesions EAE MS ultrastructure 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • H. Lassmann
    • 1
    • 2
    • 3
  • K. Kitz
    • 1
    • 2
    • 3
  • H. M. Wisniewski
    • 1
    • 2
    • 3
  1. 1.Neurological Institute of University of ViennaViennaAustria
  2. 2.Institute of Micromorphology and Electronmicroscopy of the University of ViennaAustria
  3. 3.N.Y.S. Institute of Basic Research in Mental RetardationUSA

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