Endothelial Surface Charge: Blood-Brain Barrier Opening to Horseradish Peroxidase Induced by the Polycation Protamin Sulfate

  • Z. Nagy
  • H. Peters
  • I. Hüttner
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 7)


Perfusion of rat brain with the polycation protamin sulfate caused a decrease in the stainability of luminal surface of cerebral endothelium to positively charged colloidal iron. This change reflecting a decrease in the anionic sites of the endothelial plasma membrane was accompanied by opening of the blood-brain barrier to horseradish peroxidase. The polyanion heparin reversed colloidal iron binding but failed to prevent permeability alteration of the cerebral endothelium.

Key words

blood-brain barrier polycation protein endothel 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Z. Nagy
    • 1
  • H. Peters
    • 2
  • I. Hüttner
    • 2
  1. 1.Department of PsychiatrySemmelweis Medical UniversityBudapestHungary
  2. 2.Department of PathologyMcGill University MontrealCanada

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