Neurogenic Disorders of ADH Secretion. Clinical and Neuropathological Correlations
The major neurogenic disturbances of water and salt regulation are diabetes insipidus (ADH deficiency), essential hypernatremia, inappropriate ADH secretion, compulsive water drinking and hypodipsia (Fig. 1). In general, central dysregulation of water and salt balance is due to diffuse hypothalamic lesions or by large suprasellar tumours. We report four clinical cases in which the clinical features differ widely from one patient to another; such different abnormalities of fluid balance seems to be related to different lesions of the hypothalamic-neurohypophysial axis.
Key wordsdiabetes insipidus hypernatremia osmostasis
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