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Neurogenic Disorders of ADH Secretion. Clinical and Neuropathological Correlations

  • M. Scanarini
  • D. d’Avella
  • M. Zuccarello
  • G. C. Andrioli
Conference paper
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 7)

Abstract

The major neurogenic disturbances of water and salt regulation are diabetes insipidus (ADH deficiency), essential hypernatremia, inappropriate ADH secretion, compulsive water drinking and hypodipsia (Fig. 1). In general, central dysregulation of water and salt balance is due to diffuse hypothalamic lesions or by large suprasellar tumours. We report four clinical cases in which the clinical features differ widely from one patient to another; such different abnormalities of fluid balance seems to be related to different lesions of the hypothalamic-neurohypophysial axis.

Key words

diabetes insipidus hypernatremia osmostasis 

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References

  1. 1.
    Andersson B, Olsson K (1977) Evidence for periventricular sodiumsensitive receptors of importance in the regulation of ADH secretion. Neurohypophysis Int Conf Key Biscayne, Fla 118–127, 1976. Karger, BaselGoogle Scholar
  2. 2.
    Buggy J, Johnson AK (1977) Preoptic-hypota-lamic periventricular lesions: thirst deficits and hypernatremia. Am J Physiol 233:R44-R52PubMedGoogle Scholar
  3. 3.
    Crompton MR (1963) Hypotalamic lesions following the rupture of cerebral berry aneurysms. Brain 86:301PubMedCrossRefGoogle Scholar
  4. 4.
    Hayward JN, Vincent JD (1970) Osmosensitive single neurones in the hypotalamus of unanaesthetized monkeys J Physiol 210:947–972.PubMedGoogle Scholar
  5. 5.
    Hilton SM, Spyer KM (1971) Participation of the anterior hypotalamus in the baroreceptor reflex. J Physiol 218:271–293PubMedGoogle Scholar
  6. 6.
    Lascelles PT, Lewis PD (1972) Hypodipsia and hypernatremia associated with hypotalamic and suprasellar lesions. Brain 95:249–264PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1981

Authors and Affiliations

  • M. Scanarini
    • 1
  • D. d’Avella
    • 1
  • M. Zuccarello
    • 1
  • G. C. Andrioli
    • 1
  1. 1.Institute of NeurosurgeryUniversity of PaduaItaly

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