Comparison of Clinical Trials in Acute Myelogenous Leukaemia by use of a Mathematical Model

  • R. R. P. Jackson
  • L. J. Moullin
  • W. Gregory
  • R. Bell
  • J. M. A. Whitehouse
  • T. A. Lister
Part of the Medizinische Informatik und Statistik book series (MEDINFO, volume 26)


We describe the development and application to clinical trials of a mathematical model of patient behaviour in acute myelogenous leukamia (AML). Observed patient behaviour in a trial can be compared with predictions made by a model derived from another set of trial data and deviations from these predictions identified and assessed. This form of analysis is applicable to trials in progress, allowing early detection of trends and differences.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • R. R. P. Jackson
    • 1
  • L. J. Moullin
    • 2
  • W. Gregory
    • 1
  • R. Bell
    • 3
  • J. M. A. Whitehouse
    • 4
  • T. A. Lister
    • 3
  1. 1.Research Centre for the Mathematical Modelling of Clinical TrialsUniversity of WarwickCoventryUK
  2. 2.National Coal BoardLondonUK
  3. 3.ICRF Department of Medical OncologySt. Bartholomew’s HospitalLondonUK
  4. 4.CRC Wessex Medical Oncology Unit CF93Southampton General HospitalSouthamptonUK

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