Recognition: the Kinetic Concepts

  • J. Ninio
  • F. Chapeville
Part of the Molecular Biology, Biochemistry and Biophysics book series (MOLECULAR, volume 32)

Abstract

Following Pauling’s analysis (Pauling 1948, 1958), most enzymologists relate enzyme specificity to the supposed geometric complementarity between enzyme and substrate, the structural match being realized either at the initial stage of binding or later during the formation of a transition complex (Koshland 1958; Wolfenden 1972; Fersht 1974; Jencks 1975). The concept of stereochemical complementarity (Fischer 1894), which is fundamental to our understanding of the replication of the genetic material (Pauling and Delbrück 1940; Watson and Crick 1953), was invoked whenever there was a problem of molecular specificity, from immunology (Ehrlich 1900; Haurowitz 1967) to molecular evolution (Woese 1967). Yet there is now a rapidly growing body of knowledge which is being produced and organized along a quite different mode of thinking. The following are a few examples of recent experimental findings which created difficulties for the geometric viewpoint and contributed to the spread of the kinetic ideas.

Keywords

Hydrolysis Codon Catalysis Bacillus Stein 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1980

Authors and Affiliations

  • J. Ninio
    • 1
  • F. Chapeville
    • 1
  1. 1.Institut de Recherche en Biologie MoleculaireUniversite de ParisParis Cedex 05France

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