Recognition of Ligands by Haem Proteins

  • M. F. Perutz
Part of the Molecular Biology, Biochemistry and Biophysics book series (MOLECULAR, volume 32)

Abstract

How does haemoglobin recognise its substrate, oxygen, and discriminate against its toxic inhibitor, CO? What makes haemoglobin an oxygen carrier and cytochrome b5 an electron transfer enzyme? Why is the peroxidase activity of methaemoglobin so weak, compared with peroxidase enzymes, seeing that their absorption spectra and many of their reactions are so similar? What role does the porphyrin play in all these proteins? The oxygen affinity of haemoglobin is lowered by a variety of physiologically important ligands. How does haemoglobin recognize them?

Keywords

Cobalt Superoxide Carboxylate Pyridine Serine 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1980

Authors and Affiliations

  • M. F. Perutz
    • 1
  1. 1.MCR Laboratory of Molecular BiologyCambridgeGreat Britain

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