Advertisement

Recognition of Ligands by Haem Proteins

  • M. F. Perutz
Part of the Molecular Biology, Biochemistry and Biophysics book series (MOLECULAR, volume 32)

Abstract

How does haemoglobin recognise its substrate, oxygen, and discriminate against its toxic inhibitor, CO? What makes haemoglobin an oxygen carrier and cytochrome b5 an electron transfer enzyme? Why is the peroxidase activity of methaemoglobin so weak, compared with peroxidase enzymes, seeing that their absorption spectra and many of their reactions are so similar? What role does the porphyrin play in all these proteins? The oxygen affinity of haemoglobin is lowered by a variety of physiologically important ligands. How does haemoglobin recognize them?

Keywords

Haem Iron Oxygen Carrier Haem Protein Oxygen Affinity Haem Pocket 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin · Heidelberg 1980

Authors and Affiliations

  • M. F. Perutz
    • 1
  1. 1.MCR Laboratory of Molecular BiologyCambridgeGreat Britain

Personalised recommendations