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Regulation of Muscle Contraction by Ca Ion

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Chemical Recognition in Biology

Part of the book series: Molecular Biology, Biochemistry and Biophysics ((MOLECULAR,volume 32))

Abstract

There is no doubt that the contractile processes of every kind of muscle are solely regulated by Ca ion. The fundamental evidence for this concept was furnished by the laboratory of Professor Fritz Lipmann in 1959.

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References

  • Aksoy MO, Williams D, Sharkey EM, Hartshorne DJ (1976) Relationship between Ca2+ sensitivity and phosphorylation of gizzard actomyosin. Biochem Biophys Res Commun 69: 35–41

    Article  PubMed  CAS  Google Scholar 

  • Amphlett GW, Vanaman TC, Perry SV (1976) Effect of the troponin C-like protein from bovine brain (Brain Modulator Protein) on the Mg2+-stimulated ATPase of skeletal muscle actomyosin. FEBS Lett 72: 163–168

    Article  PubMed  CAS  Google Scholar 

  • Berson G (1974) Ca2+, Sr2+ and Ba2+ sensitivity of tropomyosin-troponin complex from cardiac and fast skeletal muscles. In: Drabikowski W, Strzelecka-Golaszewska H, Carafoli E (eds) Calcium binding proteins, pp 197–201. PWN-Polish Scientific Publishers, Warszawa

    Google Scholar 

  • Bremel RD, Sobieszek A, Small JV (1977) Regulation of actin-myosin interaction in vertebrate smooth muscle. In: Stephens NL (ed) Biochemistry of smooth muscle, pp 533–549. Univ. Park Press, Baltimore

    Google Scholar 

  • Casteels R, Godfraind T, Rüegg JD (1977) Excitation contraction coupling in smooth muscle. Elsevier/North-Holland, Amsterdam

    Google Scholar 

  • Chacko S, Conti MA, Adelstein RS (1977) Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation. Proc Natl Acad Sci USA 74: 129–133

    Article  PubMed  CAS  Google Scholar 

  • Cheung WY (1970) Cyclic 3’,5’-nueleotide phosphodiesterase: Demonstration of an activator. Biochem Biophys Res Commun 38: 533–538

    Article  PubMed  CAS  Google Scholar 

  • Ebashi S (1960) Calcium binding and relaxation in the actomyosin system. J Biochem 48: 150–151

    CAS  Google Scholar 

  • Ebashi S (1961) Calcium binding activity of vesicular relaxing factor, J Biochem 50: 236–244

    CAS  Google Scholar 

  • Ebashi S (1963) Third component participating in the superprecipitation of ‘Natural actomyosin’. Nature 22: 1010–1012

    Article  Google Scholar 

  • Ebashi S (1979) Ca2+ ion and muscle contraction. In: Stoclet JC (ed) Advances in pharmacology and therapeutics, vol III, pp 81–98. Pergamon Press, Oxford

    Google Scholar 

  • Ebashi S (1980) Regulation of muscle contraction. Proc R Soc London Ser B 207: 259–286

    Article  CAS  Google Scholar 

  • Ebashi S, Endo M (1968) Calcium ion and muscle contraction. Prog Biophys Mol Biol 18: 123–183

    Article  PubMed  CAS  Google Scholar 

  • Ebashi S, Lipmann F (1962) Adenosine triphosphate-linked concentration of calcium ions in a particulate fraction of rabbit muscle. J Cell Biol 14: 389–400

    Article  PubMed  CAS  Google Scholar 

  • Ebashi S, Kodama A, Ebashi F (1968) Troponin, I. Preparation and physiological function. J Biochem 64: 465–477

    PubMed  CAS  Google Scholar 

  • Ebashi S, Endo M, Ohtsuki I (1969) Control of muscle contraction. Q Rev Biophys 2: 351–384

    Article  PubMed  CAS  Google Scholar 

  • Ebashi S, Nonomura Y, Toyo-oka T, Katayama E (1976) Regulation of muscle contraction by the calcium-troponin-tropomyosin system. In: Duncan CJ (ed) Calcium in biological systems; Symp. of the Soc. for Exp. Biol, vol XXX, pp 349–360. Cambridge Univ. Press, London

    Google Scholar 

  • Ebashi S, Mikawa T, Hirata M, Toyo-oka T, Nonomura Y (1977) Regulatory proteins in smooth muscle. In: Casteels R, Godfraind T, Rüegg JD (eds) Excitation contraction coupling in smooth muscle, pp 325–334. Elsevier/North-Holland, Amsterdam

    Google Scholar 

  • Ebashi S, Nonomura Y, Mikawa T, Hirata M, Saida K (1979) Regulatory mechanisms of muscle contraction. In: Hatano T, Sato H, Ishikawa H (eds) Cell motility, molecule and organization, pp 225–237. Univ. of Tokyo Press, Tokyo

    Google Scholar 

  • Ikebe M, Aiba T, Onishi H, Watanabe S (1978) Calcium sensitivity of contractile protein from chicken gizzard muscle. J Biochem 83: 1643–1656

    PubMed  CAS  Google Scholar 

  • Kakiuchi S, Yamazaki T, Nakajima H (1970) Properties of a heat stable phosphodiesterase activating factor isolated from brain extract. Proc Japan Acad 46: 587–592

    CAS  Google Scholar 

  • Kendrick-Jones J, Lehman W, Szent-Györgyi AG (1970) Regulation in molluscan muscles. J Mol Biol 54: 313–326

    Article  PubMed  CAS  Google Scholar 

  • Kielley WW, Meyerhof O (1948) Studies on adenosinetriphosphatase of muscle. II. A new magnesium activated adenosinetriphosphatase. J Biol Chem 176: 591–601

    PubMed  CAS  Google Scholar 

  • Kitazawa T (1976) Physiological significance of Ca uptake by mitochondria in the heart in comparison with that by cardiac sarcoplasmic reticulum. J Biochem 80: 1129–1147

    PubMed  CAS  Google Scholar 

  • Kohama K (1979) Divalent cation binding properties of slow skeletal muscle troponin in comparison with those of cardiac and fast skeletal muscle troponins. J Biochem 86: 811–820

    PubMed  CAS  Google Scholar 

  • Kohama K (1980) Role of the high affinity Ca binding site of troponin. J Biochem 88: 591–599

    PubMed  CAS  Google Scholar 

  • Kumagai H, Ebashi S, Takeda F (1955) Essential relaxing factor in muscle other than myokinase and creatine Phosphokinase. Nature 176: 166–168

    Article  PubMed  CAS  Google Scholar 

  • Marsh BB (1951) A factor modifying muscle fibre syneresis. Nature 167: 1065–1066

    Article  PubMed  CAS  Google Scholar 

  • Mikawa T (1979) ‘Freezing’ of the calcium-regulated structures of gizzard thin filaments by glutar-aldehyde. J Biochem 85: 879–811

    PubMed  CAS  Google Scholar 

  • Mikawa T, Toyo-oka T, Nonomura Y, Ebashi S (1977) Essential factor of gizzard ‘Troponin’ fraction. J Biochem 81: 273–275

    PubMed  CAS  Google Scholar 

  • Mikawa T, Nonomura Y, Hirata M, Ebashi S, Kakiuchi S (1978) Involvement of an acidic protein in the regulation of smooth muscle contraction by the leiotonin-tropomyosin system. J Biochem 84, 1633–1636

    PubMed  CAS  Google Scholar 

  • Potter JD, Gergely J (1975) The calcium and magnesium binding sites on troponin and their role in the regulation myofibrillar adenosine triphosphatase. J Biol Chem 250: 4628–4633

    PubMed  CAS  Google Scholar 

  • Ronald ML, Umazume Y, Kushmeric MJ (1976) Ca2+ dependence of tension and ADP production in segments of chemically skinned muscle fibers. Biochim Biophys Acta 430: 352–365

    Article  Google Scholar 

  • Sherry JMF, Gorecka A, Aksoy MO, Dabrowska R, Hartshorne DJ (1978) Roles of calcium and phosphorylation in the regulation of the activity of gizzard myosin. Biochemistry 17: 4411–4418

    Article  PubMed  CAS  Google Scholar 

  • Small JV, Sobieszeck A (1977) Ca-regulation of mammalian smooth muscle actomyosin via a kinase-phosphatase-dependent phosphorylation and dephosphorylation of the 20,000-Mr light chain of myosin. Eur J Biochem 76: 521–530

    Article  PubMed  CAS  Google Scholar 

  • Solandt DY (1936) The effect of potassium on the excitability and resting metabolism of frog’s muscle. J Physiol 86: 162–179

    PubMed  CAS  Google Scholar 

  • Solaro RJ, Weise RM, Shiner JS, Briggs NL (1974) Calcium requirements for cardiac myofibrillar activation. Circ Res 34: 525–530

    PubMed  CAS  Google Scholar 

  • Weber A (1966) Energized calcium transport and relaxing factors. In: Sanadi DR (ed) Current topics in bioenergetics, pp 203–254. Academic Press, New York London

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan

    S. Ebashi, Y. Nonomura, K. Kohama, T. Kitazawa & T. Mikawa

Authors
  1. S. Ebashi
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  2. Y. Nonomura
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  3. K. Kohama
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  4. T. Kitazawa
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  5. T. Mikawa
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Editor information

Editors and Affiliations

  1. CNRS, Inst. de recherche en biologie moléculaire, Université Paris VII, Tour 43, 2 Place Jussieu, F-75221, Paris Cedex 05, France

    F. Chapeville  & A.-L. Haenni  & 

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© 1980 Springer-Verlag Berlin · Heidelberg

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Ebashi, S., Nonomura, Y., Kohama, K., Kitazawa, T., Mikawa, T. (1980). Regulation of Muscle Contraction by Ca Ion. In: Chapeville, F., Haenni, AL. (eds) Chemical Recognition in Biology. Molecular Biology, Biochemistry and Biophysics, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81503-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-81503-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81505-8

  • Online ISBN: 978-3-642-81503-4

  • eBook Packages: Springer Book Archive

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