Abstract
The immune status of the tumor-bearing patient remains poorly defined. In various solid-tumor-bearing patients, we demonstrated the absence of ADCC modifications in the patient in relapse or in evolution. These same patients presented a significant increase in immune complexes when compared with patients in remission. Furthermore, we noted a decreased NK activity, a decreased number of ARFC, corresponding to a helper T cell subpopulation, and a corollary increase in T-dependent suppressor activity. These results, on the whole, suggest an immune imbalance and that the helper cell — suppressor cell ratio should be investigated in greater depth within the context of the immune response in the cancer patient.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Broder S, Mull L, Waldmann TA (1978) Suppressor cells in neoplastic disease. J Natl Cancer Inst 61:5–11
Caraux J, Thierry C, Esteve C, Flores G, Lodise R, Serrou B (1979) Human autologous rosettes. I. Mechanism of binding of autologous erythrocytes by T cells. Cell Immunol 45:36–48
Caraux J, Thierry C, Serrou B (1979) Human autologous rosettes. II. Prognostic significance of variations in autologous rosette forming cells in the peripheral blood of cancer patients. J Natl Cancer Inst 63:593–601
Gauci L, Caraux J, Thierry C, Pujol H, Serrou B (1978) Modifications of the immune status induced in malignant melanoma patients by chemo-immunotherapy and immunotherapy. In: Serrou B, Rosenfeld C (eds) Human lymphocyte differentiation. Its application to cancer. North-Holland, Amsterdam, pp 383–386
Gauci L, Ursule E, Serrou B (1978) Circulating immune complexes in malignant melanoma. In: Thivolet J (ed) Immunopathologie cutanée, vol 80. INSERM, Paris, pp 357–366
Gauci L, Ursule E, Serrou B (1979) A semi-automated system permitting analysis of immune complex components. In: Peeters H (ed) Protides of the biological fluids. Pergamon, Oxford New York, pp 29–32
Mathé G (ed) (1976) Cancer active immunotherapy. Immunoprophylaxis and immuno-restoration. Recent Results Cancer Res 55
Mathé G, Muggia F (eds) (1980) Cancer chemo- and immunopharmacology. Recent Results Cancer Res, vol 75. Springer, Berlin Heidelberg New York
Serrou B, Cupissol D, Caraux J, Thierry C, Rosenfeld C, Goldstein AL (1980) Ability of thymosin to decrease in vivo and in vitro suppressor cell activity in tumor bearing mice and cancer patients. Recent Results Cancer Res, vol 75. Springer, Berlin Heidelberg New York
Serrou B, Rosenfeld C (1978) Human lymphocyte differentiation. Its application to cancer. North-Holland, Amsterdam
Serrou B, Rosenfeld C (1980) Immune complexes and plasmaphoresis in cancer patients, vol 1. Human Cancer Immunology. North-Holland, Amsterdam
Thierry C, Flores G, Caraux J, Valles H, Serrou B (1976) Techniques de séparation et de caractérisation de sous-populations lymphocytaires chez l’homme. In: Sabolovic D, Serrou B (eds). Techniques of separation and characterization of human lymphocytes, vol 57. INSERM, Paris, pp 15–32
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Serrou, B., Gauci, L., Caraux, J., Cupissol, D., Thierry, C., Esteve, C. (1980). Immune Imbalance in Cancer Patients. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-81491-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81493-8
Online ISBN: 978-3-642-81491-4
eBook Packages: Springer Book Archive