Antibodies as Carriers for Oncostatic Materials

  • R. Arnon
  • E. Hurwitz
  • M. Sela
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 75)

Abstract

Daunomycin conjugates to antitumor antibodies prepared either by direct binding or by binding via dextran retain both the antibody and the drug activity. Thus, they exert specific cytotoxicity in vitro toward tumor cells that the antibodies recognize. The macromolecular conjugates are able to penetrate the cells and concentrate in or on the nuclei. In vivo, the antitumor antibodies accumulate preferentially at the tumor metastases. Daunomycin-antibody conjugates are more active than the free drug in prolongation of survival of mice transplanted with the YAC lymphoma cells.

Keywords

Sugar Toxicity Filtration Lymphoma Leukemia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • R. Arnon
  • E. Hurwitz
  • M. Sela

There are no affiliations available

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