Abstract
A Pseudomonas aeruginosa (i.v.) treatment (108 killed organisms) has shown the capacity to induce the release of tumor-necrotizing factor in the serum of BCG-pretreated mice to the same extent as an LPS treatment. Lower doses of P. aeruginosa (107 killed organisms) were applied in BCG-pretreated mice (1 mg given IV 7 days prior to or 1 day after tumor graft) bearing a methylcholanthrene-induced fibrosarcoma. In both cases this combined treatment significantly delayed tumor growth without a toxic side effect.
The authors thank Nicole Saou and Myriam Bennoun for their excellent technical assistance. This work was supported by grant CRL 79.5.0362 from INSERM
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© 1980 Springer-Verlag Berlin Heidelberg
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Kiger, N., Khalil, A., Mathé, G. (1980). Tumor-Necrotizing Serum Production by Administration of BCG + Pseudomonas: Its Application in Treatment of Fibrosarcoma in Mice. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_34
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DOI: https://doi.org/10.1007/978-3-642-81491-4_34
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