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Lynestrenol: A Progesteronelike Agent with Immunostimulatory Properties

  • J. Wybran
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 75)

Abstract

Lynestrenol, a synthetic progesteronelike drug, was assessed for its influence upon human leukocyte tests in vitro and in vivo. Lynestrenol markedly enhanced the lymphocyte response to phytohemagglutinin, the mixed lymphocyte culture, the active T-rosette test, the autologous red cell rosettes, and the number of nonadherent cells in the leukocyte adherence inhibition test. All these results indicate a stimulatory effect upon human T-cell function. Lynestrenol also increased monocyte phagocytosis. Lynestrenol delayed the appearance of malignant tumors in hamsters. Finally, lynestrenol, given to lung cancer patients, increased their T-cell functions as evaluated by skin tests, T-cell rosettes, and phytohemagglutinin response. Lynestrenol does possess immunostimulatory properties.

Keywords

Herpes Simplex Virus Type Lung Cancer Patient Nonadherent Cell Mixed Lymphocyte Culture Immunostimulatory Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bloom HJ (1968) The basis for hormonal therapy. JAMA 204:605–609PubMedCrossRefGoogle Scholar
  2. 2.
    Felsburg PJ, Edelman R, Gilman R (1976) The active E rosette test: Correlation with delayed cutaneous hypersensitivity. J Immunol 116:1110–1114PubMedGoogle Scholar
  3. 3.
    Felsburg PJ, Edelman R (1977) The active E rosette test: A sensitive in vitro correlate for human delayed type hypersensitivity. J Immunol 118:62–66Google Scholar
  4. 4.
    Gerretsen G, Kremer J, Bleumink E (1975) Dinitrochlorobenzene sensitization test in women on hormonal contraceptives. Lancet 2:347–349PubMedCrossRefGoogle Scholar
  5. 5.
    Holzman RS, Lawrence HS (1977) In vitro augmentation of lymphocyte sheep cell rosette formation by leukocyte dialysates. J Immunol 118:1672–1676PubMedGoogle Scholar
  6. 6.
    Horowitz S, Groshong T, Albrecht R, Hong R (1975) The active rosette test in immunodeficiency diseases. Clin Immunol Immunopathol 4:405–414PubMedCrossRefGoogle Scholar
  7. 7.
    Keller AJ, Irvine WJ, Jordan J, London NB (1977) Phytohemagglutinin induced lymphocyte transformation in oral contraceptives users. Obset Gynecol 49:83–91Google Scholar
  8. 8.
    Munroe SJ (1971) Progesteroids as immunosuppressive agents. J Reticuloendothel Soc 9:361–375PubMedGoogle Scholar
  9. 9.
    Satho PS, Fleming WE, Johnston KE, Oznun KA (1977) Active E rosette formation in women taking oral contraceptives. N Engl J Med 296:54Google Scholar
  10. 10.
    Wybran J, Fudenberg HH (1973) Thymus derived rosette forming cells. N Engl J Med 288:1072–1073PubMedCrossRefGoogle Scholar
  11. 11.
    Wybran J, Govaerts A, Appelboom T (1978) Inosiplex, a stimulating agent for normal human T cells and human leucocytes. J Immunol 121:1184–1187PubMedGoogle Scholar
  12. 12.
    Wybran J, Govaerts A, Van Dam D, Appelboom T (to be published) Stimulating properties of lynestrenol on normal human blood T lymphocytes and leucocytes. Int Immunophar-macolGoogle Scholar
  13. 13.
    Wybran J, Levin AS, Fudenberg HH, Goldstein AL (1975) Thymosin: Effects on normal human blood T cells. Ann NY Acad Sci 249:300–307PubMedCrossRefGoogle Scholar
  14. 14.
    Wybran J, Thiry L (1978) Delay of tumor growth in hamsters treated with lynestrenol and effect of Staphylococcus aureus Cowan. J Natl Cancer Inst 61:173–176PubMedGoogle Scholar
  15. 15.
    Wybran J, Van Bogaert E, Govaerts A (1977) Lynestrenol, an amplifier of lymphocyte stimulation. Biomedecine 27:16–19PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • J. Wybran

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