Bestatin Treatment and the Peripheral Lymphocyte Population in Cancer Patients

  • H. Blomgren
  • L. E. Strender
  • F. Edsmyr
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 75)


Bestatin, a substance produced by Streptomyces olivoreticuli, inhibits certain cell-membrane-associated enzymes and has been shown to augment immune responses in experimental animals. We have determined whether bestatin medication changed the peripheral lymphocyte population in 15 advanced cancer patients. After 2 weeks of daily, 30 mg oral bestatin medication, the lymphocyte counts remained essentially unchanged, but the frequency of E-rosette-forming lymphocytes increased. In vitro stimulation of the lymphocytes with PHA or PPD remained essentially unchanged while the natural-killer activity of the lymphocyte population increased in most patients. Bestatin treatment caused no detectable side effects.


Purify Protein Derivative Leucine Aminopeptidase Chang Liver Cell Human Leukocyte Interferon Cytotoxic Index 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • H. Blomgren
  • L. E. Strender
  • F. Edsmyr

There are no affiliations available

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