Abstract
Microorganisms are the treasury of organic compounds which have various structures and various biologic and medicinal activities. The study of inhibitors of enzymes on the cellular surface has led to the findings of immunomodulators; bestatin, amastatin, forphenicine, and esterastin. Bestatin enhances delayed-type hypersensitivity to SRBC and oxazolone and inhibits Gardner lymphosarcoma and IMC-carcinoma in mice. It also suppressed Ps. aeruginosa infection in mice treated with an immunosuppressive agent. Bestatin has extremely low toxicity and has been studied clinically. These studies on bestatin were reviewed.
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Aoike A, Tanaka Y, Hosokawa T, Kawai K (1979) Effect of bestatin on natural killer cell. Bestatin Conference, March 10, Tokyo 1979
Aoyagi T, Suda H, Nagai M, Ogawa K, Suzuki J, Takeuchi T, Umezawa H (1976) Aminopeptidase activities on the surface of mammalian cells. Biochim Biophys Acta 452:131–143
Aoyagi T, Tobe H, Kojima F, Hamada M, Takeuchi T, Umezawa H (1978) Amastatin, an inhibitor of aminopeptidase A produced by actinomycetes. J Antibiot (Tokyo) 31:636–638
Aoyagi T, Yamamoto T, Kojiri K, Kojima F, Hamada M, Takeuchi T, Umezawa H (1978) Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycytes. J Antibiot (Tokyo) 31:244–246
Blomgren H, Strender LE, Edsmyr F (1979) Studies on the immunostimulatory effect of bestatin in vitro and in vivo. Bestatin Conference, March 10, Tokyo 1979
Ishizuka M, Iinuma H, Takeuchi T, Umezawa H (1972) Effect of diketocoriolin B on antibody-formation. J Antibiot (Tokyo) 25:320
Ishizuka M, Takeuchi T, Umezawa H (1979) Further study of effect of bestatin on immune responses. Bestatin Conference, March 10, Tokyo 1979
Kunimoto T, Umezawa H (1973) Kinetic studies on the inhibition of (Na+ + K+)-ATPase by diketocoriolin B. Biochim Biophys Acta 318:78–90
Suda H, Aoyagi T, Takeuchi T, Umezawa H (1976) Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomers. Arch Biochem Biophy 177:196–200
Tsuruo T, Kataoka T, Tsukagoshi S, Sakurai Y (1979) Effect of bestatin on lymph node metastasis of P388. Bestatin Conference, March 10, Tokyo
Umezawa H (1972) Enzyme inhibitors of microbial origin. University of Tokyo
Umezawa H (1976) Structures and activities of protease inhibitors of microbial origin. In: Lorand L (ed) Methods in enzymology 45, part B. Academic, New York, pp 678–695
Umezawa H (1977) Recent advances in bioactive microbial secondary metabolites. J Antibiot 30 [Suppl]: 138–163
Umezawa H, Aoyagi T, Hazato T, Uotani K, Kojima F, Hamada M, Takeuchi T (1978) Esterastin, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo) 31:639–641
Umezawa H, Aoyagi T, Suda H, Hamada M, Takeuchi T (1976) Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot (Tokyo) 29:97–99
Umezawa H, Ishizuka M, Aoyagi T, Takeuchi T (1976) Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase. J Antibiot (Tokyo) 29:857–859
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© 1980 Springer-Verlag Berlin Heidelberg
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Umezawa, H. (1980). Screening of Small Molecular Microbial Products Modulating Immune Responses and Bestatin. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_19
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DOI: https://doi.org/10.1007/978-3-642-81491-4_19
Publisher Name: Springer, Berlin, Heidelberg
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