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Increased Resistance to Tumor Graft in Mice Infected by Vaccinal Strains of Brucella Abortus

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Cancer Chemo- and Immunopharmacology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 75))

Abstract

Kinetics of proliferation in vivo and the effect on murine tumors of the vaccinal strain Brucella abortus B19 and two derivatives, 19BA and B19R, were studied. Inocula of 5 × 106 organisms of each strain produced comparable infections peaking on day 8. Several protocols of Brucella treatment yielded favorable results in EL4 lymphoma and Lewis tumor. The treatment for EL4 lymphoma seemed optimal 8–14 days after infection with 5 × 106 — 5 × 107 organisms. In comparison with BCG, Brucella grew faster in vivo and accumulated more in the spleen. The effects of BCG and Brucella were comparable on EL4 lymphoma, but BCG was less effective than Brucella on Lewis tumor. The results encourage trials using live Brucella vaccine as an antitumor agent in man.

We are grateful to A. Gaudin for her skilled technical assistance. This work was supported by INSERM contract 78.4.1832 and DGRST contract 76.7.1687

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Authors
  1. L. Dazord
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  2. Y. le Garrec
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  3. M. Bonnier
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  4. L. Toujas
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Editors and Affiliations

  1. Institut de Cancérologie et Immunogénétique, Hôpital Paul-Brousse, 14-16 Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Georges Mathé

  2. Division of Oncology, Department of Internal Medicine, Institute of Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, NY, 10016, USA

    Franco M. Muggia

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© 1980 Springer-Verlag Berlin Heidelberg

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Dazord, L., le Garrec, Y., Bonnier, M., Toujas, L. (1980). Increased Resistance to Tumor Graft in Mice Infected by Vaccinal Strains of Brucella Abortus. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-81491-4_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81493-8

  • Online ISBN: 978-3-642-81491-4

  • eBook Packages: Springer Book Archive

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