Skip to main content

Some “Pharmacologic” Data About Corynebacterium Parvum

  • Chapter
Cancer Chemo- and Immunopharmacology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 75))

Abstract

It is obviously irrelevant to discuss pharmacologic characteristics of Corynebacterium parvum, this being not a biochemically defined agent, but a killed freeze-dried bacteria, with a very complex membrane. This bacteria is not submitted to metabolic processes like a drug. It first behaves like a very complicated group of antigens. In addition, it possesses nonspecific stimulating properties on the reticuloendothelial system, and its effects depend upon the state of the immunosystem at the time it is injected. For these reasons, it seems likely that the fate of C parvum in the body, like other complex microorganisms, will never be described in terms of pharmacology. Nevertheless, some data grossly relevant to this field can be summarized here.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barth RF, Singla O (1978) Organ distribution of technetium-99m-labeled Corynebacterium parvum in normal and tumor-bearing mice. Cancer Res 38:32–37

    PubMed  CAS  Google Scholar 

  2. Creasman WT, Gall SA, Blessing JA, Schmidt HJ, Abu-Ghazaleh S, Whisnant JK, DiSaia PJ (1979) Chemoimmunotherapy in the management of primary stage III ovarian cancer: A gynecologic oncology group study. Cancer Treat Rep 63:319–323

    PubMed  CAS  Google Scholar 

  3. Fisher B, Linta J, Hanlon J, Saffer E (1978) Further observations on the inhibition of tumor growth by Corynebacterium parvum with cyclophosphamide. V. Comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of Mycobacterium butyricum, BCG, and a nonviable aqueous ether extract of Brucella abortus preparation in treatment of mice with tumors. J Natl Cancer Inst 60:391–398

    PubMed  CAS  Google Scholar 

  4. Fisher B, Wolmark N, Saffer E, Fisher ER (1975) Inhibitory effect of prolonged Corynebacterium parvum and cyclophosphamide administration on the growth of established tumors. Cancer 35:134–143

    Article  PubMed  CAS  Google Scholar 

  5. Foster RS Jr, McPherson BR, Browdie DA (1977) Effect of Corynebacterium parvum on colony-stimulating factor and granulocyte-macrophage colony formation. Cancer Res 37:1349–1355

    PubMed  Google Scholar 

  6. Hattori T, Yamagata S (1975) Combination of non-specific immunopotentiation with Corynebacterium parvum liquefaciens and chemotherapy in tumor-bearing mice. Gann 66:711–715

    PubMed  CAS  Google Scholar 

  7. Israel L (1974) Non-specific immuno-stimulation in bronchogenic cancer. Scand J Respir Dis [suppl] 89:95–105

    CAS  Google Scholar 

  8. Israel L A randomized study of chemotherapy versus chemotherapy and immune therapy with Corynebacterium parvum in advanced breast cancer. In: Ambrosiana Milano (ed) Conferences, symposium, workshops of the XIth International Cancer Congress, Florence 1974, vol I, pp 222–223

    Google Scholar 

  9. Israel L (1975) Report on 414 cases of human tumors treated with Corynebacteria. In: Halpern B (ed) Corynebacterium parvum. Plenum, New York London, pp 389–401

    Chapter  Google Scholar 

  10. Israel L (1976) Immunochemotherapy with Corynebacterium parvum in disseminated cancer. Ann NY Acad Sci 277:241–251

    Article  PubMed  CAS  Google Scholar 

  11. Israel L, Depierre A (1976) Combination of Corynebacterium parvum and cytostatic drugs in disseminated human cancers. Chemotherapy 7:351–354

    Article  Google Scholar 

  12. Israel L, Edelstein R (1975) Nonspecific immunostimulation with Corynebacterium parvum in human cancer. In: The Williams & Wilkins Company (ed) Immunological aspects of neoplasia. The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, pp 485–504

    Google Scholar 

  13. Israel L, Edelstein R, Depierre A, Dimitrov N (1975) Daily intravenous infusions of Corynebacterium parvum in twenty patients with disseminated cancer: A preliminary report of clinical and biologic findings. J Natl Cancer Inst 55:29–33

    PubMed  CAS  Google Scholar 

  14. Israel L, Halpern B (1972) Le Corynebacterium parvum dans les cancers avancés. Nouv Presse Med 1:19–23

    PubMed  CAS  Google Scholar 

  15. Israel L, Samak R Monocyte chemotactism as related to stage and clinical situation in cancer patients. 4th Annual Meeting of the Medical Oncology Society. Abstract 58, Nice 1978, p 15

    Google Scholar 

  16. Israel L, Samak R A modified skin window technique as a staging tool in solid tumors. Correlation between nonspecific monocyte mobilization in vivo and spread of disease. Proceedings of the 70th Annual Meeting of the AACR. Abstract 195, New Orleans, May 16–19, 1979, p 49

    Google Scholar 

  17. Scott MT (1979) Analysis of the principles underlying chemo-immunotherapy of mouse tumours. I. Treatment with cyclophosphamide followed by Corynebacterium parvum. Cancer Immunol Immunother 6:107–112

    Article  Google Scholar 

  18. Scott MT (1979) Analysis of the principles underlying chemo-immunotherapy of mouse tumours. II. Treatment with Corynebacterium parvum followed by cyclophosphamide. Cancer Immunol Immunother 6:113–119

    Article  Google Scholar 

  19. Scott MT, Milas L (1977) The distribution and persistence in vivo of Corynebacterium parvum in relation to its antitumor activity. Cancer Res 37:1673–1679

    PubMed  CAS  Google Scholar 

  20. Suit HD, Sedlacek R, Wagner M, Orsi L (1975) Radiation response of C3H fibrosarcoma enhanced in mice stimulated by Corynebacterium parvum. Nature 255:493–494

    Article  PubMed  CAS  Google Scholar 

  21. Tuttle RL, North RJ (1975) Mechanisms of antitumor action of Corynebacterium parvum: Nonspecific tumor cell destruction at site of an immunologically mediated sensitivity reaction to C. parvum. J Natl Cancer Inst 55:1403–1411

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Israel, L. (1980). Some “Pharmacologic” Data About Corynebacterium Parvum. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81491-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81493-8

  • Online ISBN: 978-3-642-81491-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics