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Metabolic Conversion of Methotrexate in Man

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Cancer Chemo- and Immunopharmacology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 74))

Summary

Metabolism of methotrexate (MTX) to closely related analogues has been increasingly recognized in recent years. 7-Hydroxymethotrexate, 2,4-diamino-N 10-methylpteroic acid, and methotrexate poly-γ-glutamates have been established as products of metabolic conversion in man. The significance of the formation of these metabolites has not been firmly established. Certain of these compounds may play a role in the development of the renal failure syndrome associated with high-dose infusions, contribute to the chronic toxicity of MTX administration, and cross-react to a significant degree in radioimmunoassay methods for measurement of MTX concen- trations.

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Authors
  1. R. C. Donehower
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Editors and Affiliations

  1. Institut de Cancérologie et Immunogénétique, Hôpital Paul-Brousse, 14 - 16 Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Georges Mathé

  2. Medical Center, Division of Oncology, Department of Internal Medicine, Institute of Environmental Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Franco M. Muggia

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© 1980 Springer-Verlag Berlin Heidelberg

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Donehower, R.C. (1980). Metabolic Conversion of Methotrexate in Man. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81488-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-81488-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81490-7

  • Online ISBN: 978-3-642-81488-4

  • eBook Packages: Springer Book Archive

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