Abstract
Hairy-cell leukaemia (HCL) is an established clinicopathological entity typified by a chronic picture of substantial splenomegaly, less frequent hepatomegaly, and only inconspicuous lymphadenopathy. Central to the diagnosis is the pathognomonic hairy cell (HC), a distinctive mononuclear cell that circulates in varying numbers and infiltrates a variety of organs, including the bone marrow and spleen. Peripheral pancytopenia is often present, and circulating HCs may be infrequent. HCs are invariably present in the bone marrow; but, perhaps because of the extensive fibrosis characteristic of the disease, the marrow is frequently difficult to aspirate, and confirmation of the diagnosis may require histopathological examination of biopsy material.
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© 1980 Springer-Verlag Berlin Heidelberg
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Cawley, J.C., Burns, G.F., Hayhoe, F.G.J. (1980). Introduction. In: Hairy-Cell Leukaemia. Recent Results in Cancer Research, vol 72. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81437-2_1
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DOI: https://doi.org/10.1007/978-3-642-81437-2_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81439-6
Online ISBN: 978-3-642-81437-2
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