Estrogen Receptor Determination Predicts Response to Tamoxifen Therapy

  • J. C. Allegra
  • M. E. Lippman
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 71)


Tamoxifen (TAM, ICI 46,474) is a nonsteroidal antiestrogen of the triphenylethylene family. The clinical use of TAM was first reported in 1971 (Cole et al., 1971), and early clinical trials suggested that TAM was useful in the treatment of metastatic breast cancer (Cole et al., 1971; Ward, 1973; Cole et al., 1972). These studies yielded response rates ranging between 15% and 60% with minimal toxicity.


Breast Cancer Estrogen Receptor Metastatic Breast Cancer Advanced Breast Cancer Estrogen Receptor Status 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • J. C. Allegra
    • 1
  • M. E. Lippman
    • 1
  1. 1.Medicine Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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