Lack of Estrogen Receptor Associated with an Increased Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer?

  • M. E. Lippman
  • J. C. Allegra
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 71)

Abstract

Recent advances in the management of metastatic breast cancer have led to a significant improvement in patient care. A variety of new kinds of endocrine therapy, such as antiestrogen administration or medical adrenalectomy with aminoglutethimide, have reduced the toxicity of endocrine therapy. The use of steroid receptor determinations has improved the selection of patients for endocrine therapy enormously, such that about 75% accuracy in patient assignment for or against endocrine therapy can be anticipated.

Keywords

Leukemia Stratification Methotrexate Glucocorticoid Androgen 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • M. E. Lippman
    • 1
  • J. C. Allegra
    • 1
  1. 1.Medicine Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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