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Tamoxifen in Advanced Breast Cancer: Experience of the SAKK (Schweizerische Arbeitsgruppe für Klinische Krebsforschung — Swiss Cooperative Oncology Group)

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Endocrine Treatment of Breast Cancer

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Abstract

The Swiss Cooperative Oncology Group has had very wide experience of treating patients with advanced breast cancer, both with endocrine and with cytotoxic therapy. The Swiss Group therefore gratefully accepted the opportunity of testing tamoxifen, as a new and promising, nonsteroid hormone-like substance, in a group of patients with metastatic breast cancer, most of whom had already received some anticancer treatment.

Participating member institutions of SAKK were: Onkologische Abteilung, Medizinische Universitätsklinik und -Poliklinik, Kantonsspital, Basel (G. A. Nagel, J. P. Obrecht). Onkologische Abteilung, Inselspital, Bern (K. W. Brunner, R. W. Sonntag). Division d’Oncologie-Hématologie, Clinique médicale universitaire, Hôpital cantonal, Genève (P. Alberto, L. Wagenknecht). Service d’Oncologie, Hôpital des Cadolles, Neuchâtel (P. Siegenthaler). Abteilung für Onkologie und Hämatologie, Medizinische Klinik C, Kantonsspital, St. Gallen (H. J. Senn, W. F. Jungi). Servizio d’Oncologia, Ospedale San Giovanni, Bellinzona (F. Cavalli). Onkologische Abteilung, Medizinische Universitätsklinik, Universitätsspital, Zürich (G. Martz, C. Sauter). Onkologische Station, Medizinische Poliklinik, Kantonsspital Winterthur (T. Kroner). Onkologische Station, Medizinische Klinik, Kantonsspital Luzern (H. J. Schmid, F. Riedler).

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References

  • Cavalli, F., Alberto, P., Jungi, W. F., Martz, G., Brunner, K. W.: Tamoxifen alone or combined with multiple drug chemotherapy in disseminated breast carcinoma. Proc. 10th Internat. Congress Chemotherapy, Zürich, Vol. II, pp. 1286–1287. Washington: Amer. Soc. Microbiol. 1978

    Google Scholar 

  • Cole, M. P., Jones, C. T. A., Todd, I. D. H.: A new anti-oestrogenic agent in late breast cancer — an early clinical appraisal of ICI 46474. Br. J. Cancer 25, 210–214 (1971)

    Article  Google Scholar 

  • Ferrazzi, E., Cartei, G., De Besi, P., Fornasiero, A., Palù, G., Paccagnella, A., Sperandio, P., Fosser, V., Grigoletto, E., Fiorentino, M.: Tamoxifen in disseminated breast cancer. Tumori 63, 463–468 (1977)

    PubMed  CAS  Google Scholar 

  • Golder, M. P., Phillips, M. E. A., Baum, M., Griffiths, K., Fahmy, D. R., Henk, J. M., Jones, V., Preece, P. E.: Hormones in breast cancer patients on tamoxifen. Br. J. Cancer 32, 246–247 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Harper, M. J. K., Walpole, A. L.: A new derivative of triphenylethylene: effect on implantation and mode of actions in rats. J. Reprod. Fertil. 13, 101–119 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Henningsen, B., Amberger, H.: Antiöstrogene Therapie des metastasierenden Mammakarzinoms. Dtsch. Med. Wochenschr. 102, 713–716 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Heuson, J. C.: Current overview of EORTC clinical trials with tamoxifen. Cancer Treat. Rep. 60, 1463–1466 (1976)

    PubMed  CAS  Google Scholar 

  • Jordan, V. C.: Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. Cancer Treat. Rep. 60, 1409–1419 (1976)

    PubMed  CAS  Google Scholar 

  • Jungi, W. F., Alberto, P., Wagenknecht, L., Cavalli, F., Martz, G., Brunner, K. W.: Antiöstrogene: eine neue endokrine Behandlungsmöglichkeit beim metatasierenden Mammakarzinom. Schweiz. Med. Wochenschr. 108, 1317–1321 (1978)

    PubMed  CAS  Google Scholar 

  • Kiang, D. T., Kennedy, B. J.: Tamoxifen (antioestrogen) therapy in advanced breast cancer. Ann. Intern. Med. 87, 687–690 (1977)

    PubMed  CAS  Google Scholar 

  • Leclercq, G., Heuson, J. C.: Therapeutic significance of sex-steroid hormone receptors in the treatment of breast cancer. Eur. J. Cancer 13, 1205–1215 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Legha, S. S., Carter, S. K.: Antiestrogens in the treatment of cancer. Cancer Treat. Rev. 3, 205–216 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Legha, S. S., Davis, H. L., Muggia, F. M.: Hormonal therapy of breast cancer: new approaches and concepts. Ann. Intern. Med. 88, 69–77 (1978)

    PubMed  CAS  Google Scholar 

  • Lerner, H. J., Band, P. R., Israel, L., Leung, B. S.: Phase II study of tamoxifen: Report of 74 patients with stage IV breast cancer. Cancer Treat. Rep. 60, 1431–1435 (1976)

    PubMed  CAS  Google Scholar 

  • Lippman, M.: Hormone-responsive human cancer in continuous tissue culture. In: Breast cancer. Heuson, J. C., Mattheiem, W. H., Rosencweig, M. (eds.), pp. 111–139. New York: Raven Press 1976

    Google Scholar 

  • Lippman, M., Bolan, G., Huff, K.: Interactions of antiestrogens with human breast cancer in long-term culture. Cancer Treat Rep. 60, 1421–1429 (1976)

    PubMed  CAS  Google Scholar 

  • Manni, A., Trujillo, J., Marshall, J. S., Pearson, O. H.: Antiestrogen-induced remissions in stage IV breast cancer. Cancer Treat. Rep. 60, 1445–1450 (1976)

    PubMed  CAS  Google Scholar 

  • Morgan, L. R., Schein, P. S., Wolley, P. V., Hoth, D., MacDonald, J., Lippmann, M., Posey, L. E., Beazley, R. W.: Therapeutic use of tamoxifen in advanced breast cancer. Cancer Treat. Rep. 60, 1437–1443 (1976)

    PubMed  Google Scholar 

  • Moseson, D. L., Sasaki, G. H., Kraybill, W. G., Leung, B. S., Davenport, C. E., Fletcher, W. S.: The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. Cancer 41, 797–800 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Nicholson, R. I., Golder, M. P.: The effects of synthetic antiestrogens on the growth and biochemistry of rat mammary tumors. Eur. J. Cancer 11, 571 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Nicholson, R. I., Davies, P., Griffith, K.: Effects of oestradiol-17 and tamoxifen on nuclear oestradiol-17 receptors in DMBA-induced rat mammary tumors. Eur. J. Cancer 13, 201–208 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Nordenskjöld, B., Löwhagen, T., Westerberg, H., Zajicke, J.: 3H-Thymidine incorporation into mammary carcinoma cells obtained by needle aspiration before and during endocrine therapy. Acta Cytol. (Baltimore) 20, 137–143 (1976)

    Google Scholar 

  • Roberts, M. M., Forrest, A. P. M., Hamilton, T., Langlands, A. O., Lutz, Q., McFayden, J. J., Stewart, H. J.: Preliminary report of a controlled trial in advanced breast cancer comparing tamoxifen with conventional hormone therapy. Cancer Treat. Rep. 60, 1461–1462 (1976)

    PubMed  CAS  Google Scholar 

  • Sponzo, R. W., Barkley, J. B., Horton, J., Cunningham, T. J.: Tamoxifen in the management of advanced breast cancer. Proc. Am. Assoc. Cancer Res. 17, 68 (1976)

    Google Scholar 

  • Szepesi, T., Czech, W.: Klinische Beurteilung der Anti-Oestrogensubstanz Tamoxifen in der Behandlung des metastasierenden Mammakarzinoms. Wien. Klin. Wschr. 90, 133–141 (1978)

    PubMed  CAS  Google Scholar 

  • Tagnon, H. J.: Antiestrogens in treatment of breast cancer. Cancer 39 (Suppl.), 2959–2964 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Tormey, D. C., Simon, R. M., Lippman, M. J., Bull, J. M., Myers, C. E.: Evaluation of tamoxifen dose in advanced breast cancer: a progress report. Cancer Treat. Rep. 60, 1451–1459 (1976)

    PubMed  CAS  Google Scholar 

  • Viladiu, R., Bosch, F. X., Benito, E., Alonso, M. C.: Antiestrogen tamoxifen in the treatment of advanced breast cancer: a series of 31 patients. Cancer Treat. Rep. 61, 899–900 (1977)

    PubMed  CAS  Google Scholar 

  • Ward, H. W. C.: Combined anti-prolactin and anti-oestrogen therapy for breast carcinomas. Clin. Oncol. 3, 1–5 (1977)

    Google Scholar 

  • Ward, H. W. C.: Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br. Med. J. 1978 I, 13–14

    Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik C, Abteilung für Onkologie und Hämatologie, Kantonspital, CH-9007, St. Gallen, Switzerland

    W. P. Jungi, P. Alberto & F. Cavalli

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  1. W. P. Jungi
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  2. P. Alberto
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  3. F. Cavalli
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Editors and Affiliations

  1. Chirurgische Klinik, Klinikum der Universität Heidelberg, Kirschnerstraße 1, D-6900, Heidelberg 1, Germany

    B. Henningsen  & F. Linder  & 

  2. ICI-Pharma, Clinical Research, Postfach 103109, D-6900, Heidelberg 1, Germany

    C. Steichele

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© 1980 Springer-Verlag Berlin Heidelberg

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Jungi, W.P., Alberto, P., Cavalli, F. (1980). Tamoxifen in Advanced Breast Cancer: Experience of the SAKK (Schweizerische Arbeitsgruppe für Klinische Krebsforschung — Swiss Cooperative Oncology Group). In: Henningsen, B., Linder, F., Steichele, C. (eds) Endocrine Treatment of Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81406-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-81406-8_18

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