Abstract
Proteins are synthesized with specific structural information that determine their topology. Based in part on experimental evidence and in part on theoretical considerations, one can distinguish four groups of protein sequence that are determinants for protein topology. These are: (1) signal sequences, (2) stop-transfer sequences, (3) insertion sequences, and (4) sorting sequences. Signal sequences trigger translocation of proteins across distinct cellular membranes. Stop-transfer sequences abrogate translocation. Both sequences interact with specific membrane proteins that function as translocators. Insertion sequences serve to integrate monotopic integral membrane proteins into the lipid bilayer without the help of translocators. Sorting sequences function to route protein traffic following translocation or integration into membranes.
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References
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Blobel, G. (1979). Determinants in Protein Topology. In: Holzer, H., Tschesche, H. (eds) Biological Functions of Proteinases. Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1979 in Mosbach/Baden, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81395-5_9
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DOI: https://doi.org/10.1007/978-3-642-81395-5_9
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