Lysosomes and Intracellular Proteolysis

  • R. T. Dean
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1979 in Mosbach/Baden book series (MOSBACH, volume 30)


Most of the general features of protein turnover are described elsewhere in this volume, by Bohley and by Goldberg, and several excellent and detailed reviews are available (1–3). My purpose here is to outline available information on lysosomal mechanisms of degradation of endogenous cellular proteins.


Mouse Peritoneal Macrophage Lysosomal System Thiol Proteinase Intracellular Proteolysis Lysosomal Proteolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Goldberg AL, Dice JF (1974) Annu Rev Biochem 43: 835PubMedCrossRefGoogle Scholar
  2. 2.
    Goldberg AL, St John AC (1976) Annu Rev Biochem 45: 747PubMedCrossRefGoogle Scholar
  3. 3.
    Ballard FJ (1978) Essays Biochem 13: 1Google Scholar
  4. 4.
    Barrett AJ, Heath MF (1977) In: Dingle JT (ed) Lysosomes: A laboratory handbook. North Holland, Amsterdam, p 19Google Scholar
  5. 5.
    Barrett AJ (ed) (1977) Proteinases in mammalian cells and tissues. North Holland, Amsterdam, p 7 36Google Scholar
  6. 6.
    Ohkuma S, Poole B (1978) Proc Nat Acad Sci USA 75: 3327PubMedCrossRefGoogle Scholar
  7. 7.
    Dean RT (1979) Eur J Rheumatol Inflamm in pressGoogle Scholar
  8. 8.
    Dean RT, Barrett AJ (1976) Essays Biochem 12: 1PubMedGoogle Scholar
  9. 9.
    Novikoff AB (1973) In: Hers HG, van Hoof F (eds) Lysosomes and storage diseases. Academic Press, London New York, p 1Google Scholar
  10. 10.
    Mortimore GE, Ward WF (1976) In: Dingle JT, Dean RT (eds) Lysosomes in biology and pathology, Vol V. North Holland, Amsterdam, p 157Google Scholar
  11. 11.
    Umezawa H, Aoyagi T (1977) In: Barrett AJ (ed) Proteinases in mammalian cells and tissues. North Holland, Amsterdam, p 637Google Scholar
  12. 12.
    Dean RT (1975) Nature (London) 257: 414CrossRefGoogle Scholar
  13. 13.
    Dean RT (1979) Biochem J 180: in pressGoogle Scholar
  14. 14.
    Dean RT, Hylton W, Allison AC (1979) Biochim Biophys Acta in pressGoogle Scholar
  15. 15.
    Mego JL, Farb RM (1978) Biochem J 172: 233PubMedGoogle Scholar
  16. 16.
    Dean RT (1975) Biochem Biophys Res Commun 67: 604PubMedCrossRefGoogle Scholar
  17. 17.
    Dean RT (1978) Biochem Biophys Res Commun 85: 815PubMedCrossRefGoogle Scholar
  18. 18.
    Seglen PO (1977) Acta Biol Med Germ 36: 1789PubMedGoogle Scholar
  19. 19.
    Poole B, Ohkuma S, Warburton MJ (1977) Acta Biol Med Germ 36: 1777PubMedGoogle Scholar
  20. 20.
    Wildenthal K, Wakeland JR, Morton PC, Griffin EE (1978) Circ Res 42: 787–792PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • R. T. Dean
    • 1
  1. 1.School of Biological SciencesBrunel UniversityUxbridge, MiddlesexUK

Personalised recommendations